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. 2021 May 22;23:146. doi: 10.1186/s13075-021-02524-9

Fig. 1.

Fig. 1

Flow chart depicting inclusion and exclusion criteria for opioid user cohorts. Cross-sectional opioid use was defined by the MIFUSE variable (MIFUSE = 1). Longitudinal opioid use was defined as opioid use at baseline and 4-year follow-up (MIFUSE = 1, respectively) and opioid use duration of at least 1 year at follow-up (MIFDUR ≥ 3)