Table 2.

Differences in baseline scores^a

	Unadjustedc			Adjustedd
Score	Coef.b	95% CI	Pe	Coef.b	95% CI	Pe
WORMSf
Total	7.2	5.4, 9.1	< 0.001	7.1	5.5, 8.8	< 0.001
Cartilage	2.6	1.8, 3.5	< 0.001	2.6	1.8, 3.4	< 0.001
Meniscus	1.9	1.3, 2.4	< 0.001	1.9	1.4, 2.4	< 0.001
BMEL	0.6	0.2, 0.9	0.006	0.5	0.2, 0.9	0.006
Subchondral cyst	1.0	0.6, 1.4	< 0.001	0.9	0.6, 1.3	< 0.001
KOOSg
QOL	−12.9	−16.7, −9.1	< 0.001	−12.2	−15.8, −8.5	< 0.001
Symptom	−6.6	−8.8, −4.4	< 0.001	−6.0	−8.0, −3.8	< 0.001
Pain	−10.0	−12.9, −7.1	< 0.001	−9.2	−12.1, −6.4	< 0.001

^aOpioid users, n = 181; controls, n = 362. ^bCoefficients indicate differences in scores between opioid users and controls. ^cUnadjusted linear regression models, reflecting raw baseline differences. ^dLinear regression models, adjusted for age, sex, body mass index, race, and baseline Kellgren-Lawrence grade. ^fSignificant P values are printed bold. ^eA higher WORMS score indicates worse structural knee damage. ^gKOOS scores range from 0 to 100, with lower KOOS scores reflecting worse reported knee problems. WORMS, Whole-Organ Magnetic Resonance Imaging score; KOOS, Knee injury and Osteoarthritis Outcome Score; BMEL, bone marrow edema-like lesions; QOL, quality of life; Coef., coefficient; 95% CI, 95% confidence interval