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Cumulative incidence curves for SSS age of onset based on KRT8 p.Gly62Cys genotype (A) in deCODE and (B) in CHB-CVS/DBDS. Aalen–Johansen estimator was used, treating death as a competing risk.56 Age of onset was determined by the first registered ICD diagnosis of SSS available to us and thus represents an upper range (Supplementary material online, Methods).
