Table 1.

Association results for lead variants at loci reaching genome-wide significance in a meta-analysis of sick sinus syndrome including 6469 cases and 1 000 187 controls

Locus number	Rs-name/Chr: position (hg38)	Effect allele/other	EAFa (%)	Variant annotation	Coding change	Closest gene	OR (95% CI)	P-value	P-value threshold
1	rs387906656b/chr14:23396970	A/G	0.34	Missense	p.Arg721Trp	MYH6	8.88 (6.97–11.32)	7.5 × 10−70	2.6 × 10−8
2	rs7689774/chr4:110782354	T/G	20.07	Intergenic	–	MIR297, PITX2	1.21 (1.15–1.26)	2.0 × 10−15	1.2 × 10−9
3	rs11554495/chr12:52904798	A/C	1.64	Missense	p.Gly62Cys	KRT8	1.62 (1.43–1.84)	9.4 × 10−14	2.6 × 10−8
4	rs12932445/chr16:73035989	C/T	20.10	Intronic	–	ZFHX3	1.16 (1.11–1.21)	8.1 × 10−10	1.2 × 10−9
5	rs35813871c/chr2:178785681	A/G	26.63	Missense	p.Thr811Ile	TTN	1.13 (1.09–1.18)	5.7 × 10−9	2.6 × 10−8
	rs34883828c/chr2:178905448	A/C	15.23	Missense	p.Glu382Asp	CCDC141	1.15 (1.09–1.21)	1.1 × 10−7	2.6 × 10−8
6	rs6795970/chr3:38725184	A/G	35.78	Missense	p.Val1073Ala	SCN10A	1.12 (1.07–1.16)	2.5 × 10−8	2.6 × 10−8

CI, confidence interval; OR, odds ratio.

^aEffect allele frequency in Iceland (deCODE).

^bVariant exclusive to Iceland.

^cp.Thr811Ile in TTN and p.Glu382Asp in CCDC141 are weakly correlated: R²= 0.20, D’ = 0.64.