Fig. 2.

CD151 downregulation alleviated the neutrophil and monocyte infiltration after ischemic stroke. a Neutrophil infiltration with a zoomed version (scale bar = 50 μm). Black arrows indicated MPO-positive cells. b Monocyte infiltration with a zoomed version (scale bar = 50 μm). Black arrows indicated CD115-positive cells. c Neutrophil infiltration decreased 24 and 72 h after reperfusion in vivo (n = 3 per group). ** vs. LV Vehicle + MCAO indicates p < 0.01. d The MPO activity, which was used as a neutrophil activation indicator, was reduced in the LV CD151 shRNA + MCAO group 24 and 72 h after reperfusion in vivo (n = 6 per group). ** and **** vs. LV Vehicle + MCAO indicate p < 0.01 and 0.0001, respectively. e Monocyte infiltration decreased 24 and 72 h after reperfusion in vivo (n = 3 per group). ** vs. LV Vehicle + MCAO indicates p < 0.01