Fig. 6.

Timetable illustrating important discoveries in MCET biology. Four years after the first description of NETs by Brinkmann et al., MCETs were identified by Köckritz-Blickwede and colleagues in 2008. Over the past 5 years, a variety of stimuli for MCET formation have been described, including various microbes, microbial products, and chemicals, and several neoplastic MC cell lines and organ-derived MCs were reported to generate MCETs