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. 2021 Mar 1;162(6):bqab045. doi: 10.1210/endocr/bqab045

Figure 1.

Figure 1.

Effect of T and DHT supplementation on body weight and body composition of HFD-fed chemically castrated male WT mice. Male WT mice were chemically castrated with degarelix and supplemented with placebo (DGX), T (DGX + T), or DHT (DGX + DHT) at 16 weeks of age. From 16 to 36 weeks of age, all animals were subjected to HFD (n = 12/group). Body weight (A) and body composition (B–C) of 16- to 36-week-old mice. Fat (D) and lean (E) body mass were normalized to body weight. Data were analyzed with two-way ANOVA with Bonferroni post hoc test. ####P < 0.0001 comparison between DGX and DGX + T. +P < 0.05, ++P < 0.01, +++P < 0.001, ++++P < 0.0001 comparison between DGX and DGX + DHT. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 comparison between DGX + T and DGX + DHT. Data are represented as mean ± SEM. Abbreviations: ANOVA, analysis of variance;BW, body weight; DGX, degarelix; DHT, dihydrotestosterone; HFD, high fat diet; SEM, standard error of the mean; T, testosterone; WT, wild type.