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. 2021 Mar 1;162(6):bqab045. doi: 10.1210/endocr/bqab045

Figure 2.

Figure 2.

Effect of T and DHT supplementation on the weight of androgen-sensitive tissues and fat pads of HFD-fed chemically castrated male WT mice. Male WT mice were chemically castrated with degarelix and supplemented with placebo (DGX), T (DGX + T), or DHT (DGX + DHT) at 16 weeks of age. From 16 to 36 weeks of age, all animals were subjected to HFD (n = 12/group). Body weight (A) and body composition (B) of 36-week-old mice. C: Fat and lean body mass of 36-week-old mice were normalized to body weight. Weight of seminal vesicles (D) and levator ani muscle (E) of 36-week-old mice. Weight of various fat pads of white adipose tissue (F) and brown adipose tissue (G) of 36-week-old mice. Data were analyzed with one-way ANOVA with Bonferroni post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are represented as mean ± SEM. Abbreviations: ANOVA, analysis of variance;BAT, brown adipose tissue; BW, body weight; DGX, degarelix; DHT, dihydrotestosterone; F, fat; HFD, high fat diet; LA, levator ani; SEM, standard error of the mean; Subq, subcutaneous; SV, seminal vesicles; T, testosterone; WT, wild type.