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. 2021 Mar 1;162(6):bqab045. doi: 10.1210/endocr/bqab045

Figure 6.

Figure 6.

Effects of T supplementation on the weight of androgen-sensitive tissues and fat pads of HFD-fed chemically castrated male N-ERαKO mice. Male N-ERαKO mice were injected with degarelix and supplemented with placebo (DGX, n = 6) or T (DGX + T, n = 8) at 16 weeks of age and subsequently fed with HFD for 20 weeks. Body weight (A) and body composition (B) of 36-week-old mice. C: Fat and lean body mass of 36-week-old mice were normalized to body weight. Weight of seminal vesicles (D) and levator ani (E) of 36-week-old mice. Weight of various fat pads of white adipose tissue (F) and brown adipose tissue (G) of 36-week-old mice. Data were analyzed with unpaired two-tailed t-test. ****P < 0.0001. Data are represented as mean ± SEM. Abbreviations: BAT, brown adipose tissue; BW, body weight; DGX, degarelix; F, fat; HFD, high fat diet; LA, levator ani; N-ErαKO, extrahypothalamic neuron-specific estrogen receptor α knockout; SEM, standard error of the mean; Subq, subcutaneous; SV, seminal vesicles; T, testosterone.