Comparison 5. ARNI versus usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
5.1 Cardiovascular mortality (RR)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.2 Heart failure hospitalisation, first (RR)	2	7362	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.80, 1.00]
5.3 Heart failure hospitalisation (HR)	2	7362	Hazard Ratio (IV, Fixed, 95% CI)	0.87 [0.76, 0.99]
5.4 Hyperkalaemia	2	5054	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.77, 1.01]
5.5 All‐cause mortality (RR)	3	7663	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.84, 1.11]
5.6 Withdrawal due to adverse event	3	7663	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.91, 1.14]