Study	Reason for exclusion
ACTRN12610001087044	Trial registry entry suggested two parts of a trial of which only the second was of interest to this review. Contact with trialists confirmed that the part of interest was registered and reported on separately (ACTRN: 12614000088640, STRUCTURE study).
Adgey 1992	Population does not meet protocol
Ammon 2001	Wrong study design
Andersson 1996	Population does not meet protocol
Andersson 1999	Population does not meet protocol
Andersson 2000	Population does not meet protocol
Anonymous 1996	Population does not meet protocol
Anonymous 1999	Wrong intervention
Anonymous 2000	Population does not meet protocol
Anonymous 2001	Wrong study design
Anonymous 2002	Wrong study design
Anonymous 2003	Wrong comparator
Anonymous 2003a	Wrong study design
Anonymous 2003b	Wrong study design
Anonymous 2003c	Population does not meet protocol
Anonymous 2005	Population does not meet protocol
Anonymous 2008	Wrong study design
Anonymous 2008a	Wrong study design
Anonymous 2013	Wrong study design
ANZ HF carvedilol	Subgroup of participants of interest (LVEF = 40‐44%). We did not receive a response from the trialists to our enquiry for details on the subgroup of interest.
Aoyama 2007	Wrong study design
Apostolovic 2013	Wrong comparator
Apostolovic 2014a	Wrong comparator
Apostolovic 2014b	Wrong comparator
Arena 2007	Wrong study design
Armstrong 1999	Wrong study design
Aronow 1991	Wrong study design
Aronow 2001	Wrong study design
Axelsson 2015	Population does not meet protocol
Balaban 2007	Turkish paper. Translated methods and data extraction. Unclear if participants had heart failure. We did not receive a response from the investigator when we asked for clarification.
Bao 2005	Population does not meet protocol
Barr 1995	Population does not meet protocol
Barrios 2009	Population does not meet protocol
Barry 2003	Wrong study design
Bartels 1999	Population does not meet protocol
Baruch 1999	Ineligible participants. Emailed trialists to clarify inclusion criteria. Response received: "Our study was confined to individuals with a reduced ejection fraction and the data therefore would not be applicable to your quest."
Baruch 2004	Population does not meet protocol
Bauersachs 2004	Wrong study design
Baumhakel 2008	Wrong study design
Bellenger 2004	Population does not meet protocol
Berry 2001	Wrong study design
Bettencourt 1999	Wrong study design
Beygui 2016	Population does not meet protocol
Blagodar 2003	Population does not meet protocol
Blomer 1990	Wrong study design
Borghi 2011	Wrong comparator
Borgi 1990	Population does not meet protocol
Borlaug 2014	Wrong study design
Bornkessel 1992	Population does not meet protocol
Bounhoure 1991	EF not reported. Could not identify current contact details.
Braunwald 2004	Population does not meet protocol
Brilla 1989	Wrong study design
Brilla 1991	EF unclear, unclear whether allocation was random, unable to identify current contact details.
Bristow 1994	Population does not meet protocol
Bristow 1996	Population does not meet protocol
Bussmann 1987	EF unclear. We did not receive a response to our enquiry for details.
Butler 2017	Population does not meet protocol
Cafaro 2010	Wrong study design
Cardoso 1999	Wrong study design
Castagno 2010	Population does not meet protocol
ChiCTR1800016350	Wrong comparator
Choi 2001	Population does not meet protocol
Cicoira 2002	subgroup of participants of interest; we did not receive a response from the trialist to our enquiry for details.
Cleland 1984	unclear EF. contacted trialists. no response
Cleland 1999	Population does not meet protocol
Cleland 2001	Population does not meet protocol
Cleland 2003	Population does not meet protocol
Cleland 2004	Wrong study design
Cleland 2006	Wrong study design
Cleland 2007	Wrong study design
Cleland 2010	Wrong study design
Cleland 2011	Wrong study design
Cleland 2013	Wrong study design
Cohen‐Solal 2005	Population does not meet protocol
Cohn 1993	Wrong study design
Cohn 1996a	Wrong study design
Cohn 1996b	Wrong study design
Cohn 2007	Wrong study design
Coletta 2008	Wrong study design
Coletta 2009	Wrong study design
Comin‐Colet 2002	Wrong study design
CONSENSUS	EF unclear. We did not receive a response from the trialists to our enquiry for details.
CONSENSUS II	Mean EF suggests a subgroup of eligible participants. We did not receive a response from the trialists to our enquiry.
Conti 2005	Wrong study design
Corder 1993	EF unclear. Unable to identify current contact details.
Crouse 2011	Wrong study design
Dahlstrom 2007	Wrong study design
Davie 2001	Wrong study design
DeBock 1994	EF unclear. Unable to find current contact details for trialists.
Dekleva 2012	Wrong comparator
De Melo 2011	Wrong comparator
Demers 2001	Population does not meet protocol
Desai 2013	Wrong study design
Deswal 2010	EF unclear. We did not receive a response from trialists to our query on the clarification of inclusion criteria.
de Teresa 1995	Wrong study design
Ding 2008	Wrong comparator
Ditiatkov 1999	Wrong study design
Donal 2008	Wrong study design
Dragana 2015	Wrong comparator
Edner 2013	Wrong study design
Eichhorn 1994	subgroup of participants of interest; did not receive a response from trialists to our enquiry.
Eichhorn 2003	Population does not meet protocol
Er 2005	Wrong study design
Ertl 1999	Wrong study design
EudraCT 2004‐004169‐13	Trial registry record states completed but no contact details given an no published results identifiable. Sponsor: South Manchester University Hospital NHS Trust. Emailed sponsor to ask whether results are available. Unclear whether http://www.isrctn.com/ISRCTN77645264 is the same trial. Tried to contact investigator but email was undeliverable.
Fauchier 2009	Wrong study design
Feola 2003	Wrong study design
Flammer 2013	Population does not meet protocol
Flather 2016	Wrong study design
Flesch 2006	Wrong study design
Follath 1996	Wrong study design
Fonarow 2004	Wrong study design
Fonarow 2007	Population does not meet protocol
Fowler 1999	Wrong study design
Franciosa 2002	Wrong intervention
Fukunami 1991	Wrong study design
Galinier 2007	Wrong study design
Galloe 2006	Potential eligible subgroup. Did not receive a response from trialists to our enquiry for outcome data for subgroup.
Gao 2010	Could not obtain details on LVEF as inclusion criteria. No available subgroup data for population of interest.
Gardner 2003	Wrong study design
Gardner 2004	Wrong study design
Ghali 2002	Population does not meet protocol
Gheorghiade 2009	Population does not meet protocol
Good 1994	Population does not meet protocol
Goodfield 1999	Population does not meet protocol
Gottlieb 1996	Population does not meet protocol
Grajek 2008	Review
Greenberg 1996	Population does not meet protocol
Gremmler 2000	EF unclear. Unable to identify current contact details.
Groenning 2000	Population does not meet protocol
Groenning 2001	Wrong study design
Groenning 2002	Population does not meet protocol
Gruner 2007	Population does not meet protocol
Guazzi 1998	Population does not meet protocol
Guazzi 1999	Population does not meet protocol
Gøtzsche 1992	subgroup with HF and LVEF >40%. We did not receive a response from trialists to our enquiry.
Hanping 1997	Wrong study design
Hara 2000	Wrong comparator
Hauf 1993	Wrong study design
Hole 2004	Population does not meet protocol
Holland 2010	Limited information in conference abstract. Response to our enquiry for further details received: "the data you've requested was not collected on this group of patients beyond what has been published in that abstract". As we could not confirm whether the participants meet our inclusion criteria, this study was excluded.
Hong 2003	Wrong intervention
Hoppe 2007	Wrong study design
Hori 2004	Population does not meet protocol
Hung 2010	Wrong study design
IRIS‐HF	Response from trialists received when asked for outcome data for subgroup of interest: no data specifically for participants in subgroup of interest (LVEF 40‐45%) provided. Confirmed that QoL, mortality and HF hospitalisation were not formal endpoints. Hyperkalaemia was not shown by any participants.
Ito 2012	Wrong study design
Jamieson 1991	Wrong study design
Jellis 2014	HF/EF unclear. No response to our enquiry for details.
Jessup 2003	Wrong study design
Jong 2010	Wrong study design
JPRN‐jRCTs051180137	Wrong comparator
JPRN‐UMIN000006415	Population does not meet protocol
Kanoupakis 2008	Population does not meet protocol
Kapel'ko 2011	Wrong study design
Kasama 2007	Wrong comparator
Keren 1992	Population does not meet protocol
Keren 1994	Population does not meet protocol
Khalid 2013	Wrong study design
Khand 2015	Population does not meet protocol
Kikuchi 2016	Population does not meet protocol
Kimura 2011	Population does not meet protocol
Kinugawa 2007	Wrong study design
Kjekshus 2007	Wrong study design
Kjøller‐Hansen 1998	Population does not meet protocol
Kleber 1991a	No participants with heart failure with preserved ejection fraction (confirmed by trialist via email on 20 November 2017).
Kleber 1991b	Heart failure was not an inclusion criteria (confirmed by trialist via email on 15 November 2017).
Kongstad‐Rasmussen 1998	EF unclear ("ejection fraction measurement was not part of the protocol")
Krum 1996	Population does not meet protocol
Krum 2015	Population does not meet protocol
Kulbertus 2003	wrong study design
Kuznar 2003	Population does not meet protocol
Lang 1995	cross‐over trial
Larsen 1996	EF unclear. Contacted trialists. Response: data are no longer available.
Lechat 1993	LVEF unclear, otherwise eligible. Emailed investigator but did not receive a response.
Leonetti 1999	Population does not meet protocol
Lewis 1988	EF unclear. Unable to find current contact.
Li 2005	Population does not meet protocol
Liebson 2004	Population does not meet protocol
Lindenfeld 2001	Population does not meet protocol
Lindsay 1999	Wrong study design
Liu 2006	Chinese language paper. Eligibility criteria for trial unclear regarding LVEF. Emailed investigator ‐ no response.
Liu 2014	Population does not meet protocol
Logeart 2006	Wrong study design
Lopez 2000	Wrong study design
Lou 2009	Wrong study design
Luo 2007	Wrong study design
Ma 2005	Population does not meet protocol
MacGregor 2009	Population does not meet protocol
Mak 2008	EF unclear. unable to find current contact details for trialist.
Malnick 2007	Population does not meet protocol
Maron 2018	Heart failure not an inclusion criteria.
Mazayev 1998	LVEF unclear, otherwise eligible. Unable to find current contact details for investigators.
McAnulty 2004	Wrong comparator
McCullough 2012	Population does not meet protocol
McIlwain 1997	Wrong study design
McKelvie 2012	Wrong study design
McMurray 2000	Wrong study design
McMurray 2004	Wrong study design
Melo 2011	Wrong comparator
Melo 2012	Wrong comparator
Messias 2016	Wrong study design
Meuleman 2007	Population does not meet protocol
Mitrovic 2005	Wrong study design
Mochizuki 2004	retraction
Morales 2011	Population does not meet protocol
Murdoch 2001	Population does not meet protocol
NCT00293150	terminated due to lack of eligible participants
NCT00523757	Trial did not take place as planned (as per information from trialists: "We abandoned this study as we could not adequately recruit. No results to present.")
NCT01691118	Completed but no publication with results identified. Emailed trialists to ask for clarification on comparator (placebo or conventional antihypertensive treatment). No response.
NCT01944384	Completed but no results found. No contact details for investigator provided.
NCT03882710	Completed but no results found. No contact details for investigator provided.
Nodari 2003	Wrong comparator
Nunez 2016	Wrong study design
O'Callaghan 1995	Wrong study design
O'Keefe 2008	Population does not meet protocol
O'Keeffe 2015	Wrong comparator
O'Meara 2012	Population does not meet protocol
Ostergren 2004	Wrong study design
Palazzuoli 2005	Population does not meet protocol
Paolisso 1992	Wrong study design
Paraskevaidis 2006	Population does not meet protocol
Park 2016	Wrong comparator
Patten 1997	Population does not meet protocol
Pennell 2000	Population does not meet protocol
Pierard 2002	Population does not meet protocol
Pina 2004	Wrong study design
Pitt 2005	Population does not meet protocol
Pitt 2008	Population does not meet protocol
Pitt 2011	Wrong intervention
Pourdjabbar 2015	Wrong study design
Premkumar 2016	Population does not meet protocol
Quaife 1998	Population does not meet protocol
Ramaswamy 2003	Wrong study design
Remme 2001	Population does not meet protocol
Remme 2004	Population does not meet protocol
Remme 2005	Population does not meet protocol
Rimatori 1990	LVEF unclear, otherwise eligible. Unable to find current contact details for investigators.
Roongsritong 2005	Population does not meet protocol
Rosa 2011	Wrong intervention
Rosenkranz 2003	Wrong study design
Rossignol 2011	Population does not meet protocol
Sakai 2011	Wrong intervention
Sanderson 1998	Subgroup of interest LVEF 40‐45%. Investigator responded to our enquiry for data: "the mean EF was only 26.9% and I doubt any of the patients were in the group of EF 40% to <45%. [...] I do not have the original data now."
Sanghera 2011	Wrong study design
Santulli 2015	Wrong study design
Sardu 1991	LVEF not specified as an inclusion criteria, mean LVEF at baseline 35.4, 4.7%. Could not find current contact details for investigator.
Schindler 2008	Population does not meet protocol
Schwab 2009	Wrong study design
Segovia 2008	Wrong study design
Shimamoto 2007	Population does not meet protocol
Sidorenko 2008	Population does not meet protocol
Silva 2014	Population does not meet protocol
Smith 2012	Wrong study design
Spoto 2002	Wrong study design
Stecker 2005	Population does not meet protocol
Stiefelhagen 2006	Wrong study design
Struthers 2004	Wrong study design
Swedberg 1996	Wrong study design
Swedberg 1999	Wrong study design
Szajnbok 1993	Portuguese paper. Reported outcomes not of interest but subgroup of participants eligible. Emailed investigators to ask about measured outcomes for subgroup of interest. Response: data not available.
Szymanski 2009	Wrong study design
Taheri 2009	subgroup of interest LVEF 40‐45%. Contacted investigators. No response.
Takekoshi 2004	Wrong study design
Tala 2011a	Population does not meet protocol
Tala 2011b	Population does not meet protocol
Tan 2013	Wrong study design
Tatsumi 2006	Wrong study design
Taylor 2003	Wrong intervention
Teerlink 2003	Population does not meet protocol
Tereshchenko 2005	Wrong comparator
Thornton 2004	Wrong study design
Thune 2008	Population does not meet protocol
Tinoco 2004	Wrong study design
Tsutamoto 2000	Wrong study design
Tsutamoto 2001	Subgroup of interest (LVEF 40‐45%). Emailed investigators. No response.
Tsutamoto 2005	Wrong study design
Tumasyan 2010	Wrong comparator
Tumasyan 2018	Wrong comparator
Umemoto 2003	Wrong study design
Uusimaa 2001	Wrong comparator
Van den Berg 1993	Wrong study design
Van den Berg 1995	LVEF unclear; response to our enquiry for details: cannot provide data
Vasiuk 2001	Wrong study design
Vincent 2012	Population does not meet protocol
Vizir 2000	Population does not meet protocol
Vizzardi 2010	Population does not meet protocol
Vizzardi 2012	LVEF unclear. Emailed investigators. No response.
Vizzardi 2015a	Wrong study design
Vizzardi 2015b	Population does not meet protocol
Volpe 1992	Subgroup of interest LVEF 40‐45%. We received a response to our enquiry for more details on the subgroup of interest confirming that the study was conducted in "patients with reduced EF".
Volpe 2010	Population does not meet protocol
Voors 2008	Wrong study design
Waagstein 2003	Population does not meet protocol
Waldo 1995	Population does not meet protocol
Waldo 1996	Population does not meet protocol
Warner 1999	Population does not meet protocol
Weinberg 2001	Wrong study design
Weintraub 2005	Population does not meet protocol
Weir 2011	Population does not meet protocol
Wong 2002	Population does not meet protocol
Wong 2004	Population does not meet protocol
Woodley 1991	Population does not meet protocol
Wright 2014	Population does not meet protocol
Wu 2002	LVEF unclear, otherwise eligible. Unable to find current contact details for investigators.
Xu 2007	Population does not meet protocol
Yamamoto 2005	Wrong study design
Yan 2012	LVEF unclear, otherwise eligible. Unable to find current contact details for investigators.
Yoshihiro 2011	Wrong intervention
Young 2004	Population does not meet protocol
Zeng 2006	Population does not meet protocol
Zheng 2009	Was previously a study awaiting classification. Data extraction received from translator. Wrong patient population.