ChiCTR‐TRC‐09000631.

Study name	Treatment of diastolic heart failure: the role of blockade of the renin‐angiotensin system. A comparison of diuretics with an angiotensin converting enzyme inhibitor, angiotensin receptor blockade or diuretics alone
Methods	Study design: Anticipated completion date:
Participants	Estimated enrolment: 450 Inclusion criteria: "1. Signed informed consent; 2. Age >18 yrs; 3. history of heart failure for 2 months prio to screening; 4. NYHA Functional Class II‐IV; 5. LV EF >45% by ECHO or a radionucleotide technique; 6. Therapy with diuretics with stable dose >14 days prior to screening" Exclusion criteria: "1. NHYA class I; 2. Inability to answer the QOL questionnaire; 3. Myocardial infarction within 3 months; 4. unstable angina within 1 month; 5. Significant cardiac valvular heart disease; 6. Hypotension SBP <90 mmHg; 7. uncontrolled hypertension(DBP>105 ors SBP> 200 mmHg); 8. uncontrolled serious cardiac arrhythmias associated with a ventricular rate >100 bpm at study entry; 9. concurrent therapy with CCB, Betablocker, ACEI, AII or positive inotropic agents other than digoxin for control of AF"
Interventions	Ramipril + Diuretics vs. Irbesartan +Diuretics vs. Diuretics alone (comparison diuretics + irbesartan versus diuretics of interest to this review)
Outcomes	Hospital admissions for heart failure or mortality; quality of life assessed by the Minnesota Quality of life Questionnaire; exercise duration assessed by 6 min corridor walk test; side‐effects, effect on levels of natriuretic peptides, effect on doppler‐echocardiographic derived measurements of left ventricular diastolic function
Starting date	13 July 1997
Contact information	Skiva Chan: skivachan@cuhk.edu.hk
Notes	Recruitment status: completed