Table 1.
Characteristics of SPRINT (Systolic Blood Pressure Intervention Trial) participants in the ambulatory blood pressure ancillary study by orthostatic hypotension history at the 6-, 12-, or 24-month SPRINT study visit, mean (SD) or %
| Variable | Total | Orthostatic hypotension at least once during 6-, 12-, and 24-month visits | No occurrence of orthostatic hypotension |
|---|---|---|---|
| N = 897 | N = 128 | N = 769 | |
| Intensive treatment group, % | 50.5 | 44.5 | 51.5 |
| Standard treatment group, % | 49.5 | 55.4 | 48.5 |
| Age, years (27-mo) | 71.5 (9.5) | 72.8 (9.9) | 71.3 (9.4) |
| Female, % | 28.7 | 25.0 | 29.3 |
| Race/ethnicity, % | |||
| Black | 28.0 | 23.4 | 28.7 |
| White | 67.3 | 70.3 | 66.8 |
| Other | 2.3 | 4.7 | 2.0 |
| Hispanic | 2.3 | 1.6 | 2.5 |
| Body mass index, kg/m2 (24-mo) | 29.5 (5.6) | 27.9 (5.0) | 29.8 (5.7) |
| Smoking, % | |||
| Never | 46.2 | 39.1 | 47.4 |
| Former | 43.6 | 46.1 | 43.2 |
| Current | 10.2 | 14.8 | 9.4 |
| History of CKD (baseline), % | 29.2 | 30.2 | 29.1 |
| History of CVD (baseline), % | 21.7 | 25.8 | 21.1 |
| Experienced CVD event before ABPMa, % | 3.2 | 3.1 | 3.3 |
| Diabetes (24-mo), % | 2.3 | 2.3 | 2.3 |
| Stroke (24-mo), % | 0.1 | 0.0 | 0.1 |
| CKD (24-mo), % | 32.4 | 33.6 | 32.2 |
| HDL, mg/dl (24-mo) | 53.1 (17.0) | 56.2 (18.2) | 52.6 (16.7) |
| Total cholesterol, mg/dl (24-mo) | 181.0 (39.4) | 180.3 (40.5) | 181.1 (39.2) |
24-mo, data collected at 24-month annual visit; 27-mo, data collected at 27-month study visit. Abbreviations: ABPM, ambulatory BP monitoring; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate based on the Modification of Diet in Renal Disease study equation; HDL, high-density lipoprotein.
aAfter randomization.