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. 2021 May 22;3(2):lqab040. doi: 10.1093/nargab/lqab040

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Far-cis differences between the cohesin-variants. (A) Hi-C matrices of chromosome 2p of wild-type, ΔSA1 and ΔSA2. Compartment-scores are plotted on top. Bars in matrices denote 5mb and 10mb distances in red and blue, respectively. (B) Relative contact probabilities compared to wild-type in log2-space, with blue denoting ΔSA1 and red denoting ΔSA2. (C) Saddle-plots (top) and differential saddles (bottom), with purple denoting more interactions in the sample compared to the wild-type. Annotated values are the average enrichment in the 2 × 2 squares of the respective corners. (D) Boxplot of the compartmentalisation-strength per chromosome-arm (dots). *** indicates paired t-test P < .005.