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. 2021 May 22;3(2):lqab040. doi: 10.1093/nargab/lqab040

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Cohesin^SA1-only cells have diminished intra-TAD contacts. (A) Snapshots of two regions on chromosome 5 and chromosome 9, showing ΔSA1 in top-right and ΔSA2 in bottom-left triangle. (B) Aggregate Peak Analysis on TAD-corners in wild-type, ΔSA1, ΔSA2 and ΔWAPL (top). Differential APA compared to wild-type (bottom), with red denoting increased interactions in the specific sample. (C) Intersections of called TAD-boundaries in wild-type, ΔSA1 and ΔSA2. (D) Aggregate TAD analysis of Hap1 TADs in wild-type, ΔSA1, ΔSA2 and ΔWAPL (top). Differential ATA compared to wild-type (bottom), with blue denoting loss of interactions in the specific sample. (E) TAD-neighbour analysis: interactions between TADs, stratified on the number of TADs in between, compared to wild-type.