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(A) Overview of PIK3CA gene with p.E545K domain-specific mutation. (B) A model of PI3K/mTOR pathway inhibition and AR deregulation in HER2-positive salivary duct carcinoma. AKT, XXX; AR, androgen receptor; ARE, androgen receptor element; CT, computed tomography; HER2, human epidermal growth factor receptor 2; mTOR, mammalian target of rapamycin; PDK1, 3 phosphoinositidine-dependent kinase 1; PET, positron emission tomography.
