Table 2.
Quality of life (PDQ-39SI and EUROHIS-QOL8) and disability (ADLS score) in PD patients with regard to nonmotor symptoms burden: mild (NMS 1-20); moderate (NMS total score 21-40); severe (NMS total score 41-70); very severe (NMS total score > 70).
| Mild, N = 162 | Moderate, N = 174 | Severe, N = 140 | Very severe, N = 127 | p a | p b | p c | p d | |
|---|---|---|---|---|---|---|---|---|
| PDQ-39SI | 7.7 ± 5.7 | 13.8 ± 9.7 | 19.9 ± 10.7 | 32.9 ± 14.4 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Mobility | 6.2 ± 11.5 | 12.7 ± 15.6 | 19.7 ± 15.9 | 35.3 ± 22.9 | <0.0001 | <0.0001 | 0.029 | <0.0001 |
| Activities of Daily Living | 9.5 ± 11.1 | 15.8 ± 15.4 | 19.8 ± 16.7 | 32.4 ± 23.3 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Emotional well-being | 9.9 ± 10.8 | 15.6 ± 13.9 | 26.6 ± 18.7 | 41.6 ± 22.6 | <0.0001 | 0.001 | 0.149 | <0.0001 |
| Stigma | 7.6 ± 14.1 | 13.7 ± 18.9 | 10.8 ±16.2 | 22.9 ± 25.5 | <0.0001 | 0.025 | 0.001 | <0.0001 |
| Social support | 2.2 ± 8.9 | 4.9 ± 12.8 | 10.6 ± 17.5 | 18.6 ± 21.9 | <0.0001 | <0.0001 | <0.0001 | 0.001 |
| Cognition | 7.2 ± 9.6 | 16.2 ± 13.9 | 24.6 ± 16.2 | 34.9 ± 20.1 | <0.0001 | <0.0001 | 0.036 | <0.0001 |
| Communication | 3.5 ± 7.3 | 8.3 ± 12.4 | 11.6 ± 14.7 | 19.3 ± 19.7 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Pain and discomfort | 14.7 ± 15.6 | 20.7 ± 18.9 | 30.7 ± 19.6 | 47.4 ± 24.8 | <0.0001 | 0.002 | <0.0001 | <0.0001 |
| PQ-10 | 7.9 ± 1.2 | 7.5 ± 1.4 | 6.9 ± 1.4 | 6.1 ± 1.7 | <0.0001 | <0.0001 | 0.003 | <0.0001 |
| EUROHIS-QOL8 | 4.1 ± 0.5 | 3.9 ± 0.4 | 3.6 ± 0.5 | 3.3 ± 0.6 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Quality of life | 4.1 ± 0.5 | 3.9 ± 0.6 | 3.7 ± 0.7 | 3.3 ± 0.8 | <0.0001 | 0.005 | 0.001 | <0.0001 |
| Health status | 3.5 ± 0.8 | 3.3 ± 0.8 | 3 ± 0.8 | 2.6 ± 0.9 | <0.0001 | 0.001 | 0.006 | <0.0001 |
| Energy | 4.2 ± 0.7 | 3.8 ± 0.7 | 3.6 ± 0.8 | 3.2 ± 0.9 | <0.0001 | <0.0001 | 0.004 | <0.0001 |
| Autonomy for ADL | 4 ± 0.7 | 3.8 ± 0.8 | 3.4 ± 0.8 | 3 ± 0.9 | <0.0001 | 0.001 | <0.0001 | <0.0001 |
| Self-esteem | 4.2 ± 0.6 | 3.9 ± 0.7 | 3.6 ± 0.7 | 3.3 ± 0.9 | <0.0001 | 0.010 | <0.0001 | 0.001 |
| Social relationships | 4.4 ± 0.6 | 4.1 ± 0.6 | 3.9 ± 0.7 | 3.6 ± 0.8 | <0.0001 | <0.0001 | 0.059 | <0.0001 |
| Economic capacity | 4.1 ± 0.8 | 3.9 ± 0.7 | 3.8 ± 0.7 | 3.5 ± 0.9 | <0.0001 | 0.079 | 0.180 | 0.001 |
| Habitat | 4.4 ± 0.7 | 4.3 ± 0.6 | 4.2 ± 0.7 | 3.9 ± 0.7 | <0.0001 | 0.105 | 0.123 | 0.011 |
| ADLS score | 92.9 ± 6.1 | 90.2 ± 8.3 | 86.5 ± 10.4 | 80.5 ± 12.9 | <0.0001 | 0.001 | <0.0001 | <0.0001 |
| Functional dependency (%) | 0.6 | 4.6 | 11.5 | 28.3 | <0.0001 | 0.024 | 0.019 | <0.0001 |