Table 2.
Relationship (rS) between the features of BCG granuloma, the intensity of free-radical oxidation processes, and the expression of the Keap1/Nrf2/ARE signaling pathway genes.
| D | Spontaneous CL | LACL | H2O2-LACL | PECs | Nfe2l2 | NQO1 | Gstp1 | Hmox1 | |
|---|---|---|---|---|---|---|---|---|---|
| N ai | 0.63∗ | −0.24 | 0.59∗ | 0.46 | −0.70∗ | −0.43 | −0.69∗ | −0.63∗ | −0.52∗ |
| D | −0.66∗ | 0.73∗ | 0.69∗ | −0.64∗ | −0.53∗ | −0.56∗ | −0.65∗ | −0.36 | |
| Spontaneous CL | — | −0.27 | −0.29 | 0.08 | 0.51∗ | 0.47∗ | −0.10 | −0.01 | |
| LACL | 0.66∗ | −0.59∗ | −0.42 | −0.57∗ | −0.74∗ | −0.36 | |||
| H2O2-LACL | — | −0.62∗ | −0.46∗ | −0.52∗ | −0.52∗ | −0.44 | |||
| PECs | 0.40 | 0.52∗ | 0.67∗ | 0.27 | |||||
| Nfe2l2 | — | 0.69∗ | 0.06 | 0.29 | |||||
| NQO1 | 0.30 | 0.61∗ | |||||||
| Gstp1 | 0.34 |
N ai: numerical density of granulomas; D: diameter of granulomas; CL: chemiluminescence; LACL: luminol-amplified chemiluminescence; H2O2-LACL: H2O2-induced luminol-amplified chemiluminescence; PECS: DCF-dependent fluorescence of PMA-stimulated peritoneal exudate cells; Nfe2l2, NQO1, Gstp1, and Hmox1: mRNA expression of appropriate genes. ∗Significant rS values.