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. 2021 May 18;16:3429–3456. doi: 10.2147/IJN.S303412

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© 2021 Marycz et al.

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The impact of the nanocomposites alone and in combination with the miR21/124 in MF conditions on the mitochondrial potential of MC3T3-E1 cells. The results of comparative analysis, including cells with high mitochondrial membrane potential/viable (A), with the depolarised mitochondrial membrane (B) and dead (C). The metabolic activity was determined based on mitochondrial dehydrogenase activity (D). Significant differences are indicated as follows (*p<0,005, **p<0,001 and ***p<0,001) and non-significant are marked as ns. The comparisons between groups are marked with brackets. The black symbols refer to the differences between CTRL and nHAp/IO groups, while red symbols are for nHAp/IO and nHAp/IO@miR-21/124 groups.