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The impact of the nanocomposites alone and in combination with the miR21/124 on the expression on Bax (A), Bcl-2 (B),Bad (D) and ratio Bax/Bcl-2 (C) associated with apoptosis in MC3T3-E1 cell line. Significant differences are indicated as follows (*p<0,005, **p<0,001,***p<0,001, and ****p<0.0001) and non-significant are marked as ns. The black symbols refer to the differences between CTRL and nHAp/IO groups, while red symbols are for nHAp/IO and nHAp/IO@miR-21/124 groups.
