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The impact of the nanocomposites alone and in combination with the miR21/124 in condition of MF on the OPN expression (A and B) in MC3T3-E1 cell line. Significant differences are indicated as follows (**p<0,001 and ***p<0,001) and non-significant are marked as ns. The comparisons between groups are marked with brackets. The black symbols refer to the differences between CTRL and nHAp/IO groups, while red symbols are for nHAp/IO and nHAp/IO@miR-21/124 groups.
