Table 3.
Univariate and Multivariate Regression Analyses with Clinicopathologic Parameters for Epithelial Ovarian Cancer (EOC) Patient’s Prognosis
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age | 1.28(1.09–1.47) | 0.033 | 1.19(1.04–1.49) | 0.112 |
| BMI | 1.10(0.85–2.19) | 0.341 | - | - |
| Tumor size | 1.32(1.10–1.79) | 0.042 | 1.27(0.95–1.86) | 0.113 |
| Pathological grade | ||||
| G1-2 vs G3 | 1.47(1.23–1.64) | 0.038 | 1.38(1.23–1.94) | 0.042 |
| Clinical stage | ||||
| I–II vs III–IV | 2.11(1.28–3.73) | 0.009 | 1.94(1.26–3.73) | 0.015 |
| Histological type | ||||
| Serous vs others | 1.19(0.90–2.20) | 0.235 | - | - |
| CTC count | ||||
| <5 vs ≥5 | 2.03(1.64–4.04) | 0.002 | 1.95(1.55–3.96) | 0.007 |
| M-CTC percentage | ||||
| <0.3 vs ≥0.3 | 1.74(1.54–2.57) | 0.005 | 1.84(1.48–2.64) | 0.009 |
| Neutrophil | 1.22(0.84–1.92) | 0.328 | - | - |
| Lymphocyte | 0.94(0.54–2.48) | 0.281 | - | - |
| Platelet | 1.43(0.89–1.74) | 0.136 | - | - |
| Albumin | 0.84(0.54–0.93) | 0.016 | 0.89(0.64–1.02) | 0.083 |
| CA-125 | 1.43(1.04–1.74) | 0.029 | 1.34(1.03–1.84) | 0.038 |
| CA-199 | 0.98(0.85–1.35) | 0.348 | - | - |
| AFP | 1.19(0.85–1.43) | 0.193 | - | - |
| CEA | 1.25(0.94–1.86) | 0.379 | - | - |
| HE4 | 1.34(0.84–1.63) | 0.283 | - | - |
| CRP | 1.47(1.04–2.92) | 0.037 | 1.36(1.29–2.80) | 0.041 |
| HB | 1.28(0.89–1.73) | 0.326 | - | - |
| Fibrinogen | 1.58(1.18–2.10) | 0.041 | 1.39(0.99–2.39) | 0.126 |
| LDH | 1.03(0.93–2.38) | 0.275 | - | - |
| ALT | 0.94(0.75–2.02) | 0.362 | - | - |
| AST | 0.99(0.85–1.95) | 0.286 | - | - |
| TBA | 1.25(0.85–2.05) | 0.321 | - | - |
Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval; BMI, body mass index; CTC, circulating tumor cell; M-CTC, mesenchymal–CTC; HB, hemoglobin; HE4, Human epididymis protein 4, CEA, Carcinoembryonic antigen, AFP, Alpha-fetoprotein; CRP, C-reaction protein; LDH, Lactate dehydrogenase; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; TBA, total bile acid.