Table 3.
Bivariate correlations between the levels of inflammatory markers and the measures of psychopathology in PWS patients
| Anxious/depressed | Withdrawn/depressed | Somatic complaints | Social problems | Thought problems | Attention problems | Delinquent behaviour | Aggressive behaviour | |
|---|---|---|---|---|---|---|---|---|
| IL-1β | 0.225/0.163 | 0.515/0.001 | 0.386/0.014 | 0.623/< 0.001 | 0.530/< 0.001 | 0.650/< 0.001 | 0.588/< 0.001 | 0.518/0.001 |
| IL-1RA | 0.160/0.324 | 0.130/0.422 | 0.122/0.455 | 0.409/0.009 | 0.308/0.053 | 0.225/0.164 | 0.405/0.009 | 0.321/0.043 |
| IL-2 | 0.053/0.745 | 0.179/0.268 | 0.0.22/0.894 | 0.233/0.148 | 0.227/0.160 | 0.284/0.076 | 0.348/0.028 | 0.221/0.171 |
| IL-4 | 0.192/0.236 | 0.348/0.028 | 0.304/0.056 | 0.220/0.173 | 0.192/0.236 | 0.348/0.028 | 0.304/0.056 | 0.269/0.093 |
| IL-5 | − 0.276/0.089 | − 0.200/0.223 | − 0.202/0.217 | − 0.090/0.587 | − 0.191/0.243 | 0.039/0.814 | − 0.004/0.982 | 0.015/0.930 |
| IL-6 | − 0.094/0.579 | 0.028/0.867 | − 0.051/0.765 | 0.266/0.111 | 0.274/0.100 | 0.311/0.061 | 0.338/0.041 | 0.292/0.079 |
| IL− 7 | − 0.108/0.509 | − 0.119/0.463 | − 0.171/0.293 | − 0.004/0.981 | − 0.043/0.793 | 0.104/0.525 | 0.047/0.773 | 0.007/0.965 |
| IL-8 | − 0.123/0.473 | − 0.021/0.899 | − 0.111/0.495 | 0.149/0.360 | − 0.131/0.420 | 0.091/0.575 | 0.046/0.779 | 0.082/0.161 |
| IL-9 | 0.130/0.424 | 0.312/0.050 | 0.219/0.175 | 0.203/0.209 | 0.156/0.338 | 0.115/0.478 | 0.232/0.150 | 0.253/0.116 |
| IL-10 | − 0.067/0.702 | 0.018/0.918 | − 0.111/0.527 | 0.051/0.770 | − 0.010/0.954 | 0.038/0.827 | 0.216/0.213 | 0.150/0.388 |
| IL-13 | 0.117/0.471 | 0.356/0.024 | 0.174/0.284 | 0.490/0.001 | 0.387/0.014 | 0.466/0.002 | 0.483/0.002 | 0.456/0.003 |
| IL-17 | − 0.111/0.494 | − 0.129/0.426 | − 0.187/0.248 | − 0.042/0.798 | − 0.100/0.540 | 0.041/0.800 | 0.028/0.862 | − 0.048/0.771 |
| IP-10 | − 0.083/0.612 | − 0.342/0.031 | − 0.068/0.678 | − 0.045/0.782 | − 0.044/0.788 | − 0.106/0.518 | − 0.094/0.564 | 0.002/0.993 |
| MCP-1 | − 0.020/0.904 | 0.084/0.604 | − 0.102/0.530 | 0.147/0.366 | 0.166/0.477 | 0.123/0.448 | 0.151/0.352 | 0.127/0.436 |
| MIP-1α | − 0.141/0.412 | − 0.302/0.059 | − 0.250/0.119 | − 0.074/0.650 | − 0.152/0.351 | − 0.160/0.323 | − 0.133/0.413 | − 0.079/0.629 |
| MIP-1β | − 0.232/0.150 | − 0.154/0.342 | − 0.212/0.189 | − 0.113/0.489 | − 0.112/0.490 | − 0.106/0.515 | 0.062/0.704 | 0.008/0.963 |
| PDGF-BB | 0.092/0.595 | 0.075/0.665 | 0.026/0.874 | 0.102/0.529 | 0.073/0.657 | 0.019/0.909 | 0.138/0.397 | 0.030/0.855 |
| TNF-α | − 0.012/0.939 | 0.112/0.491 | 0.094/0.563 | 0.145/0.373 | 0.261/0.104 | 0.223/0.166 | 0.382/0.015 | 0.188/0.244 |
| Eotaxin-1 | − 0.284/0.075 | − 0.132/0.416 | − 0.280/0.080 | − 0.108/0.507 | − 0.123/0.449 | 0.021/0.897 | − 0.023/0.899 | − 0.050/0.761 |
| FGF-2 | − 0.063/0.700 | − 0.081/0.618 | − 0.118/0.468 | − 0.013/0.937 | − 0.054/0.739 | 0.046/0.776 | 0.017/0.916 | − 0.018/0.911 |
| G-CSF | − 0.167/0.304 | − 0.187/0.247 | − 0.214/0.185 | − 0.011/0.946 | − 0.063/0.701 | 0.093/0.568 | 0.043/0.793 | 0.046/0.779 |
Data expressed as r/p value
Significant correlations after the Benjamini–Hochberg correction were marked with bold characters
(p ≤ 0.003)
IL interleukin, IP-10 interferon-γ induced protein 10, MCP-1 monocyte chemoattractant protein-1, MIP-1α macrophage inflammatory protein-1α, MIP-1 β macrophage inflammatory protein-1β, TNF-α tumour necrosis factor α, PDGF-BB platelet-derived growth factor with two B subunits, FGF-2 fibroblast growth factor-2, G-CSF granulocyte colony-stimulating factor