Table 1A.
Differential gene expression in HS/T versus sham mice. Genes from the NanoString Mouse Autoimmune Panel with the 40 most statistically significant differences between LR-treated and sham mice are presented here and sorted by log2 fold change. Animals per group N=3 (sham, FFP, cryoprecipitate) and N=6 (LR). Genes of interest discussed in this paper are highlighted in green. *P-values adjusted by Benjamini-Yekutieli method. **Fold change of CXCL10 is skewed by one LR animal with very high expression of CXCL10; excluding this value results in a log2 fold change of 3.0 (LR vs. sham).
| Lactated Ringers (LR) | Fresh Frozen Plasma (FFP) | Cryoprecipitate | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Log2 Fold Change vs. Sham | P | Adjusted P* | Log2 Fold Change vs. Sham | P | Adjusted P* | Log2 Fold Change vs. Sham | P | Adjusted P* |
| Cxcl10 | 6.3** | 9.6E-05 | 0.02 | 0.7 | 0.60 | 1 | 1.1 | 0.39 | 1 |
| Il1b | 4.6 | 5.6E-08 | 0.0003 | 1.8 | 0.001 | 1 | 2.0 | 0.0005 | 0.21 |
| Ly6g | 4.5 | 1.4E-06 | 0.002 | 3.8 | 1.01E-05 | 0.05 | 4.6 | 1.7E-06 | 0.008 |
| Camp | 4.5 | 7.0E-05 | 0.02 | 1.5 | 0.1 | 1 | 5.2 | 6.3E-05 | 0.11 |
| Ccl4 | 4.3 | 9.7E-05 | 0.02 | 3.1 | 0.0023 | 1 | 3.8 | 0.0004 | 0.21 |
| Clec4e | 4.1 | 1.9E-07 | 0.0005 | 1.2 | 0.02 | 1 | 2.4 | 0.0001 | 0.11 |
| Nlrp3 | 3.9 | 2.6E-06 | 0.003 | 0.8 | 0.15 | 1 | 0.8 | 0.13 | 1 |
| S100a8 | 3.7 | 0.0002 | 0.03 | 1.3 | 0.12 | 1 | 3.9 | 0.0004 | 0.20 |
| Cxcl9 | 3.6 | 0.0007 | 0.08 | 0.9 | 0.35 | 1 | 1.8 | 0.06 | 1 |
| Tnfaip3 | 3.4 | 3.3E-05 | 0.01 | 0.5 | 0.45 | 1 | 1.6 | 0.02 | 1 |
| Il6 | 3.2 | 0.0002 | 0.03 | 3.0 | 0.001 | 1 | 2.3 | 0.006 | 0.88 |
| Mmp9 | 3.1 | 1.3E-05 | 0.006 | 1.8 | 0.004 | 1 | 2.6 | 0.0003 | 0.16 |
| Cd177 | 3.1 | 0.0006 | 0.07 | 0.4 | 0.57 | 1 | 2.6 | 0.004 | 0.88 |
| S100a9 | 3.1 | 3.1E-05 | 0.01 | 2.1 | 0.002 | 1 | 2.8 | 0.0003 | 0.16 |
| Hdc | 2.9 | 5.9E-07 | 0.001 | 1.0 | 0.01 | 1 | 1.9 | 0.0001 | 0.11 |
| Il1rn | 2.8 | 6.0E-05 | 0.02 | 0.1 | 0.83 | 1 | 2.0 | 0.0020 | 0.54 |
| Mefv | 2.8 | 6.5E-05 | 0.02 | 0.6 | 0.27 | 1 | 1.7 | 0.005 | 0.88 |
| Trem1 | 2.7 | 6.2E-06 | 0.004 | 1.0 | 0.01 | 1 | 1.8 | 0.0009 | 0.30 |
| Fpr1 | 2.5 | 5.8E-06 | 0.004 | 0.5 | 0.23 | 1 | 2.0 | 0.0002 | 0.13 |
| Padi4 | 2.4 | 8.1E-05 | 0.02 | 1.2 | 0.02 | 1 | 1.8 | 0.002 | 0.45 |
| Tnf | 2.3 | 0.0001 | 0.02 | 0.5 | 0.33 | 1 | 1.3 | 0.02 | 1 |
| Tlr2 | 2.2 | 3.5E-06 | 0.003 | 0.7 | 0.05 | 1 | 0.7 | 0.04 | 1 |
| Nfkbiz | 2.2 | 2.6E-05 | 0.008 | 0.7 | 0.08 | 1 | 1.0 | 0.02 | 1 |
| Ebi3 | 2.2 | 0.0004 | 0.05 | 0.5 | 0.33 | 1 | 1.7 | 0.005 | 0.88 |
| Ccr1 | 2.1 | 2.5E-05 | 0.008 | 1.0 | 0.02 | 1 | 1.4 | 0.002 | 0.57 |
| Lilrb4a | 2.0 | 0.0002 | 0.04 | −0.1 | 0.90 | 1 | 2.0 | 0.0007 | 0.26 |
| Csf3r | 1.9 | 0.0007 | 0.08 | 0.8 | 0.13 | 1 | 1.2 | 0.03 | 1 |
| Cd14 | 1.9 | 7.2E-06 | 0.004 | 0.3 | 0.39 | 1 | 1.6 | 0.0001 | 0.11 |
| Socs3 | 1.8 | 8.7E-05 | 0.02 | 0.9 | 0.03 | 1 | 1.2 | 0.005 | 0.88 |
| Fas | 1.7 | 8.9E-05 | 0.02 | 0.8 | 0.49 | 1 | 1.3 | 0.002 | 0.57 |
| Relb | 1.6 | 0.0003 | 0.05 | 0.0 | 0.95 | 1 | 0.6 | 0.14 | 1 |
| Sell | 1.4 | 5.6E-05 | 0.02 | 0.4 | 0.11 | 1 | 0.9 | 0.004 | 0.88 |
| Nfkb2 | 1.4 | 2.1E-05 | 0.008 | −0.1 | 0.79 | 1 | 0.4 | 0.11 | 1 |
| Il10ra | 1.2 | 1.5E-05 | 0.006 | 0.5 | 0.02 | 1 | 0.2 | 0.48 | 1 |
| Cd83 | 1.2 | 0.0004 | 0.05 | 0.8 | 0.01 | 1 | 1.1 | 0.001 | 0.32 |
| Nfkbia | 1.1 | 7.1E-05 | 0.02 | 0.5 | 0.02 | 1 | 0.1 | 0.61 | 1 |
| Ptprc | 1.0 | 0.0003 | 0.05 | 0.2 | 0.36 | 1 | 0.4 | 0.07 | 1 |
| Plaur | 0.9 | 1.6E-05 | 0.006 | 0.5 | 0.005 | 1 | 0.3 | 0.04 | 1 |
| Cd52 | 0.9 | 0.0004 | 0.05 | 0.4 | 0.06 | 1 | 0.8 | 0.003 | 0.75 |
| Mcl1 | 0.6 | 4.7E-05 | 0.01 | 0.1 | 0.30 | 1 | 0.5 | 0.0007 | 0.25 |