Table 1B.

Differential gene expression in HS/T mice treated with FFP or cryoprecipitate versus LR. Genes from the NanoString Mouse Autoimmune Panel with the 30 most statistically significant differences between FFP- and LR-treated animals are presented here and sorted by log₂ fold change. Animals per group N=3 (FFP, cryoprecipitate) and N=6 (LR). Genes of interest discussed in this paper are highlighted in green. *P-values adjusted by Benjamini-Yekutieli method. **Fold change of CXCL10 is skewed by one LR animal with very high expression of CXCL10; excluding this value results in a log₂ fold change of −2.2 (FFP vs. LR) and −2.1 (cryoprecipitate vs. LR).

	Fresh Frozen Plasma (FFP)			Cryoprecipitate
Gene	Log2 Fold Change vs. LR	P	Adjusted P*	Log2 Fold Change vs. LR	P	Adjusted P*
Cxcl10	−5.6**	0.0002	0.07	−5.1**	0.0004	0.3
Nlrp3	−3.1	1.9E-05	0.02	−3.0	2.3E-05	0.06
Clec4e	−2.9	4.8E-06	0.02	−1.7	0.0006	0.39
Tnfaip3	−2.9	0.0001	0.05	−1.8	0.004	1
Il1b	−2.9	6.1E-06	0.02	−2.6	1.5E-05	0.06
Il1rn	−2.6	8.6E-05	0.04	−0.7	0.13	1
Casp4	−2.5	8.0E-05	0.04	0.2	0.70	1
Dll1	−2.3	0.0008	0.14	−1.3	0.02	1
Mefv	−2.2	0.0004	0.10	−1.0	0.04	1
Vcam1	−2.1	0.0004	0.10	−0.6	0.16	1
Lilrb4a	−2.1	0.0002	0.06	0.0	0.97	1
Fpr1	−2.1	3.2E-05	0.02	−0.5	0.11	1
Hdc	−1.9	2.9E-05	0.02	−1.0	0.004	1
Il18rap	−1.9	0.001	0.21	−0.3	0.54	1
Tnf	−1.8	0.0007	0.14	−1.0	0.022	1
Ms4a4a	−1.7	0.0005	0.10	−0.4	0.24	1
Cd14	−1.6	2.5E-05	0.02	−0.3	0.24	1
Relb	−1.6	0.0003	0.08	−1.0	0.006	1
Tlr2	−1.6	8.0E-05	0.04	−1.5	9.7E-05	0.12
Fas	−1.5	0.0002	0.07	−0.4	0.17	1
Nfkbiz	−1.5	0.0006	0.14	−1.2	0.002	0.92
Nfkb2	−1.4	1.4E-05	0.02	−1.0	0.0004	0.3
Cd40	−1.4	0.0004	0.10	−1.0	0.004	1
Ripk2	−1.4	0.0007	0.14	−1.0	0.006	1
Nfe2l2	−1.3	6.1E-05	0.04	−0.2	0.35	1
Stat3	−1.3	0.0001	0.06	−0.5	0.04	1
Sell	−1.0	0.001	0.21	−0.5	0.05	1
Tbk1	−0.7	0.001	0.18	0.1	0.55	1
Il10ra	−0.7	0.002	0.22	−1.1	4.6E-05	0.08
Mcl1	−0.5	0.0003	0.08	−0.1	0.32	1