Fig. 1. Bone marrow-derived monocytes/macrophages (BMMs) had senescent phenotype after IR.

BMMs were exposed to IR at doses of 0 (ctl), 4, or 10 Gy. BMMs were collected at intervals after IR and in controls. A Representative images of SA-β-gal staining (scale bar, 100 μm) and quantification of SA-β-gal⁺ BMMs. B qRT–PCR expression of p16, p21, Bcl-2, and Bcl-xl were measured relative to Gapdh levels. Data are expressed as mean ± SEM of five independent experiments, ^***P < 0.001, ^**P < 0.01 and ^*P < 0.05 compared with the corresponding controls.