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Box–Behnken design (BBD) independent and dependent variables for the development and optimization of BRC-TL
| Variables | Used levels | ||
|---|---|---|---|
| Low (− 1) | Medium (0) | High (+ 1) | |
| Independent variables | |||
| X1 = lipoid S100 (mg) | 80 | 100 | 120 |
| X2 = cholesterol (mg) | 10 | 15 | 20 |
| X3 = sodium cholate (mg) | 5 | 10 | 15 |
| Dependent variables | |||
| Y1 = vesicles size (nm) | |||
| Y2 = entrapment efficient (%) | |||
| Y3 = in vitro release (%) | |||
