Table 3.
Dermatokinetic parameters of brucine conventional formulation (BRC-CF) gel and brucine transliposomes (BRC-TL) gel
| Dermatokinetics parameters | BRC-CF gel | BRC-TL gel | ||
|---|---|---|---|---|
| Epidermis | Dermis | Epidermis | Dermis | |
| Tskin max (h) | 1.5 ± 0.2 | 2 ± 0.1 | 1.5 ± 0.1 | 2 ± 0.15 |
| Cskin max (µg/cm2) | 50.01 ± 5.73 | 53.73 ± 3.50 | 142.9 ± 7.06 | 109.8 ± 6.74 |
| AUC0–8 (µg/cm2h) | 250.8 ± 3.93 | 250.1 ± 20.6 | 651.2 ± 23.8 | 527.5 ± 23.7 |
| Ke (h− 1) | 0.13 ± 0.01 | 0.10 ± 0.02 | 0.10 ± 0.01 | 0.08 ± 0.005 |
Tskin max, time to maximum concentration; Cskin max, maximum concentration; AUC, area under curve; Ke, elimination rate constant