Figure 4.

PfDegP activation domains in bound conformation with DFP, a mechanism-based inhibitor of DegP (a): Mechanism of Action of Di-iso Propyl fluorophosphate in synapse acting on acetylcholinesterase and inhibiting its function of breakdown of choline esters by phosphorylating the crucial serine residue (b) cell homeostasis by inhibiting the serine protease DegP by interacting with loop LA (regulatory loop) and inhibiting the activation domain (L1-L2-LD) (c) Docked pose of DFP with PfDegP in the least binding energy conformation along with the interacting residues, and interaction diagram of DFP, mechanism-based inhibitor.