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. 2021 May 22;21:273. doi: 10.1186/s12935-021-01984-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Circ_0006168 regulated Taxol resistance by affecting JMJD1C expression. Eca109/Taxol and KYSE150/Taxol cells were transfected with si-control, si-circ_0006168, si-circ_0006168 + pcDNA, or si-circ_0006168 + pcDNA-JMJD1C. A Western blot assay was used to analyze the protein abundance of JMJD1C. B, C Cell viability and IC₅₀ value of Taxol were determined by CCK-8 analysis. D, E CCK-8 assay and colony formation assay were employed to evaluate cell proliferation. F, G Cell migration and invasion abilities were assessed by transwell assay. H Flow cytometry analysis was applied to detect cell apoptosis. *P < 0.05, **P < 0.001, ***P < 0.0001