Table 5.

Mean serum concentrations of biochemical parameters in IBS-D patients with low (LS) and high scores (HS) of somatization (Subscale of SCL-90-R)

	LS (n = 19)	HS (n = 28)	P
IFABP-2 (ng/ml)	3.76 ± 5.94	2.97 ± 2.96	0.19
DAO (ng/ml)	36.10 ± 5.12	35.53 ± 4.32	0.57
Faecal Zonulin (ng/ml)	127.0 ± 67.0	180.0 ± 90.0	0.035
Serum Zonulin (ng/ml)	29.0 ± 7.1	29.0 ± 5.5	0.81
IL-6 (pg/ml)	5.76 ± 1.61	6.83 ± 7.52	0.97
IL-8 (pg/ml)	3.71 ± 0,60	5.17 ± 2.88	0.007
IL-10 (pg/ml)	3.44 ± 0.78	2.94 ± 0.28	0.02
TNF-α(pg/ml)	3.92 ± 1.22	3.57 ± 0.50	0.14

Data are expressed as means ± SD. P-value was determined by Mann–Whitney rank-sum test; differences were considered significant at P < 0.05. LS, Low somatization level; cut-off score < 63. HS, High somatization level; cut-off score ≥ 63