Table 1.

List and targets/pathways of miRNAs in myocardial I/R injury

miRNA	Change in expression	Downstream targets/pathways	Study
miR-204	downregulation	increase of LC3-II expression	[45, 46]
miR-30e	downregulation	increase of LC3B-II, Beclin-1 and p62 level	[47]
miR-221	upregulation	decrease of LC3-II expression	[48, 49]
miR-142-3p	downregulation	increase of percent of cells positive for LC3 Avs, and the level of LC3-II/LC3-I ratio, Beclin-1 and p62	[54]
miR-30a	downregulation	decrease of ULK1 and Beclin-1, and mediated by PI3K/Akt signaling axis	[55, 56, 67]
miR181a-1	downregulation	decrease of Beclin-1 expression	[57]
miR139-3p	downregulation	decrease of Beclin-1 expression	[57]
miR-325	upregulation	A E2F1/miR-325/ARC signaling axis modulating autophagy	[59]
miR-34a	downregulation	decrease of LC3-II, p62 and autophagy level	[60]
miR-429	upregulation	decrease in the number of GFP-LC3B labelled cells, vesicle and autophagosome, increase of the level of LC3BI/II, p62 and ATG13	[61]
miR-497	downregulation	decrease of autophagic flux, and increase of LC3B-II level	[62]
miR-638	downregulation	increase of autophagy via targeting ATG5	[63]
miR-431	downregulation	decrease of ATG3 expression	[64]
miR-29c	upregulation	decrease of autophagy by targeting the PTEN/AKT/mTOR signal pathway	[65]
let-7b	downregulation	decrease of Beclin-1, Atg5, Atg7 and Atg12 expression	[66]
miR-384	downregulation	increase of autophagosomes and autophagic flux, the activation of PI3K/Akt pathway	[68]
miR-17-3p	upregulation	increase of LC3II/LC3I level	[69]