Table 1.

In vivo Pharmacological Effects of α7-nAChR Ligands

Compound Name	α7 nAChR activity & other actions	Cognitive Domain Enhanced	Additional Behavioral Improvements	References
ABBF	α7 full agonist & 5-HT3 antagonist	object and social recognition, working memory		Boess et al., 2007
ABT-107	α7 full agonist	attention, working memory, social recognition	auditory gating	Bitner et al., 2010; Bordia et al., 2015; Radek et al., 2012
A-582941	α7 full agonist	working memory, social recognition, inhibitory avoidance	sensory gating	Tietje et al., 2008
AQW051	α7 partial agonist	object and social recognition, spatial reference memory		Feuerbach et al., 2015
AVL-3288 (Compound 6, CCMI or XY4083)	α7 Type I PAM	object recognition, social recognition, working memory, executive function	auditory gating, conditioned avoidance responding	Ng et al., 2007; Nikiforuk et al., 2015
BMS-933043	α7 partial agonist	object recognition, working memory, executive function	auditory gating	Bristow et al., 2016
BMS-902483	α7 partial agonist & 5-HT3 antagonist	object recognition, executive function	auditory gating	Pieschl et al., 2017
Compound 7z	α7 Type I PAM	object recognition		Hogenkamp et al., 2013
DMXB-A (GTS-21)	α7 partial agonist & 5-HT3 antagonist	attention, object recognition, spatial reference memory, working memory	sensorimotor gating	Meyer et al, 1997; Callahan et al., 2014; Jones et al., 2014
EVP-6124 (encenicline)	α7 partial agonist & 5-HT3 antagonist	object recognition		Prickaerts et al., 2012
EVP-5141	α7 full agonist & 5-HT3 antagonist	object and social recognition, working memory		Boess et al., 2013
JNJ-39393406	α7 Type I, Type II PAM	object recognition, executive function	auditory gating	Winterer et al., 2013
Lu AF58801	α7 Type I PAM	object recognition		Eskildsen et al., 2014
NS1738	α7 Type I PAM	object and social recognition, spatial reference memory		Marcus et al., 2016; Timmermann et al., 2007
PAM-2	α7 Type II PAM	object recognition, executive function	social interaction model	Potasiewicz et al., 2017
PNU 120596	α7 Type II PAM	recognition memory, spatial learning, working memory, executive function	auditory gating	Dunlop et al., 2009; Nikiforuk et al., 2015; Stevens et al., 2015
PNU-282987	α7 full agonist	recognition memory	conditioned avoidance responding	McLean et al., 2016; Marcus et al., 2016
RG 3487	α7 partial agonist & 5-HT3 antagonist	attention, object recognition, spatial reference memory, executive function	sensorimotor gating	Wallace et al., 2011
SEN-12333	α7 full agonist & histamine H3 antagonist	object recognition	sensorimotor gating	Roncarati et al., 2009
SSR-180711	α7 partial agonist	recognition memory, working memory, novelty discrimination	latent inhibition	Pichat et al., 2007; Barak et al., 2009
TC-5619	α7 full agonist	object recognition	sensorimotor gating	Hauser et al., 2009
Tropisetron	α7 partial agonist & 5-HT3 antagonist	attention, object recognition, working memory, spatial reference memory	sensorimotor gating	Callahan et al., 2017; Hashimoto et al., 2005, 2006; Kohnomi et al., 2010; Pitsikas et al., 1997