Table 1.

Criteria for Study Inclusion

	Inclusion Criteria
Populations	Patients with NF1 with PN
	Patients with NF1 without PN
Outcomes	Disease overview
	Demographics
	Clinical characteristics
	Disease progression/natural history
	Disease complications
	Impact on patient functioning and health-related quality of life
	Mortality/survival
	Treatment
	Practice patterns/treatment patterns
	Medications
	Surgery
	Resource-use estimates
	Drug utilization
	Outpatient and emergency department visits
	Imaging costs (eg, MRI, CT, PET)
	Number of hospitalizations and length of stay
	Management of drug-related adverse events
	Direct costs
	Medication costs
	Outpatient visit costs
	Hospitalization costs
	Emergency department visits
	Laboratory costs
	Diagnostic costs
	Physician costs
	Costs of managing drug-related adverse events
	Indirect or other costs of interest, including the following
	Productivity loss of patient (wages lost from absences)
	Out-of-pocket expenses
	Travel costs for patient
	Caregiver burden
Time	The database searches will be performed for the past 10 years, except for disease overview, which will be for the past 5 years
Study design	Prospective (including clinical trials), retrospective, cross-sectional, or other studies
	Systematic literature reviews
Other	Electronic database searches will be limited to articles published in the English language

Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; NF1, neurofibromatosis type 1; PET, positron emission tomography; PN, plexiform neurofibroma.