Fig. 6.

OHA-CMC/CNP/EGF hydrogel promoted wound healing in STZ-induced diabetic mice. (A) Schematic illustration of the operations on the mouse in an order of time. (B) Representative photographs of the diabetic wound at day 0, 5, 10, and 15 treated with control, OHA-CMC, OHA-CMC/CNP, OHA-CMC/EGF, and OHA-CMC/CNP/EGF groups. (C) Wound closure percentage at day 5, 10, and 15 after treatment with the five groups. (D) H&E staining images indicating the regenerated granulation tissue and epidermis in the wound region following different treatments for 10 and 15 days (white dashed line denotes the boundary of epidermis and dermis; black arrow denotes the granulation tissue). Scale bar: 500 μm. (E) Quantification of granulation tissue thickness following different treatments for 10 and 15 days. (F) Quantification of epidermal thickness following different treatments for 10 and 15 days.