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. 2021 May 20;8(1):e000426. doi: 10.1136/lupus-2020-000426

Figure 2.

Figure 2

SOCS3-cKO mice exhibit severe glomerulonephritis in the imiquimod-induced lupus model. SOCS3-cKO mice and SOCS3-WT mice were treated with or without topical imiquimod as described in the Methods section. (A) Representative photomicrograph of periodic acid-Schiff (PAS)-stained kidney sections from SOCS3-cKO mice and SOCS3-WT mice at 8 weeks. (B) Renal histopathologic scores in SOCS3-cKO mice and SOCS3-WT mice at 8 weeks. Data are means±SEM for 10 mice in each group. Data are compiled from two independent experiments. *p<0.05. (C) Serum creatinine levels in SOCS3-cKO mice and SOCS3-WT mice at 12 weeks. Data are means±SEM for 10–12 mice in each group. Data are compiled from two independent experiments. **p<0.01. (D) Urine albumin levels in SOCS3-cKO mice and SOCS3-WT mice at 12 weeks. Data are means±SEM for 8–9 mice in each group. Data are compiled from two independent experiments. *p<0.05. (E) Renal sections of SOCS3-cKO mice and SOCS3-WT mice at 8 weeks were stained with anti-IgM antibody. Shown are representative photographs. (F) The frequencies of the glomeruli having IgM deposits in 20 glomeruli were evaluated. Data are means±SEM for 10 mice in each group. Data are compiled from two independent experiments. ***p<0.001. IMQ, imiquimod; KO, knockout; SOCS, suppressor of cytokine signalling; WT, wild type.