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. 2021 May 15;29:19–29. doi: 10.1016/j.jot.2021.04.003

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

KLF10 is downregulated in degenerative NP tissues of both humans and rats. (A) Representative hematoxylin–eosin (HE) staining pictures of each Pfirrmann grade. n = 5. Scale bars:50 μm. (B–E) Immunohistochemical staining of KLF10, MMP3, collagen II and aggrecan in different degenerative disc. n = 5. Scale bars:50 μm. (F) HE and safranin-O staining of normal and IVDD rat discs. n = 5. Scale bars: 250 μm. (G) Immunohistochemical staining of KLF10 in normal and IVDD rat discs. n = 5. Scale bars:50 μm. (H) Quantitative analysis of the expression of KLF10 in human degenerative disc. (I) Quantitative analysis of the expression of KLF10 in normal and IVDD rat discs. Data are presented as the mean ± SD. ∗, P<0.05; ∗∗, P<0.01; ∗∗∗, P<0.001.