Table 3.

Angiogenesis-associated miRNAs in hepatocellular carcinoma

microRNA	Expression in HCC	Target	Effect on angiogenesis (inhibit/induce)	Model (in vivo, in vitro, human)	Type of cell line	Reference
miR-1301	down	BCL9	inhibit	in vitro, in vivo, human	Hep3B, HepG2, SMMC-7721, Huh-7	Yang et al.147
miR-26b-5p	down	VE-cadherin, snail, MMP2	inhibit	in vitro, in vivo	Bel7402, SMMC7721, HepG2, PLC, LO2	Wang et al.148
miR-199a-3p	down	VEGFA, VEGFR2, VEGFR1, HGF, MMP2	inhibit	in vitro, in vivo	HepG2, SNU449	Ghosh et al.149
miR-203a	up	HOXD3, VEGFR	inhibit	in vitro, in vivo	SMMC-7721, Hep3B	Ghosh et al.149
miR-144-3p	down	SGK3	inhibit	in vitro, in vivo, human	QGY-7703, SK-hep1	Wu et al.150
miR-497	down	VEGFA, AEG-1	inhibit	in vitro, human, in vivo	PLC/PRF/5, SMMC-7721, HepG2, Huh7, SK-HEP-1, Hep3B	Yan et al.151
miR-142	down	TGF-β	inhibit	in vitro, human	HepG-2, SMMC-7721	Yu et al.152
miR-126	up	EGFL7	inhibit	in vitro, in vivo, human	MMC-7721, MHCC-97H, HCCLM3	Yu et al.152
miR-338-3p	down	MACC1, VEGF, β-catenin	inhibit	in vitro, human	Hep3B, Huh7, HepG2, Bel-7402, HEK293T	Zhang et al.153
miR-638	down	VEGF	induce	in vitro, in vivo, human	Hep3B, SMMC-7721, HepG2, MHCC-97L, MHCC-97H	Cheng et al.154
miR-126	down	EGFL7	inhibit	in vitro, in vivo, human	HepG2, Bet-7402, SMMC-7721	Gong et al.146
miR-210	up	FGFRL1	induce	in vitro, in vivo, human	HL-7702, SMMC-7721	Yang et al.155
miR-182	up	RASA1	induce	in vitro, human	SK-HEP-1, HCC-LM3	Du et al.156
miR-126	down	Spred1	inhibit	in vitro, human		Ji et al.157
miR-26a	down	HGF	inhibit	in vitro, in vivo, human	HUVECs	Yang et al.158
miR-126-3p	down	LRP6, PIK3R2	inhibit	in vitro, human	HepG2, SMMC-7721, BEL-7402	Du et al.159
miR-195	down	VEGF, VAV2, CDC42	inhibit	in vitro, in vivo, human	MHCC-97L, Huh-7, QGY-7703, MHCC-97H, SMMC-7721	Wang et al.160
miR-302a/b/c	down	MACC1	inhibit	in vitro	cell line missing	Cao et al.161
miR-26a	down	VEGFA	inhibit	in vitro, in vivo, human	HepG2	Chai et al.162
miR-146a	up	PDGFRA	induce	in vitro, in vivo	HCCLM3	Zhu et al.141
miR-506	down	SPHK1	inhibit	in vitro, human	HepG2	Lu et al.134
miR-98 and miR-214	down	VEGF, Ang-1, MMP-2	inhibit	in vitro	HepG2	Yahya et al.163
miR-375	up	PDGFC	inhibit	in vitro, human	Hep3B, HepG2, Huh1, Huh7	Li et al.164
miR-503	down	FGF2, VEGFA	inhibit	human, in vitro, in vivo	HepG2, LO2	Zhou et al.130
miR-29b	down	MMP-2	inhibit	human, in vitro, in vivo		Fang et al.125
miR-200b	down	ERG	induce	in vitro, human	Hep3B	Moh-Moh-Aung et al.165