Table 4.
Angiogenesis-related miRNAs in gastric cancer
| microRNA | Expression in gastric cancer | Target | Effect on angiogenesis (inhibit/induce) | Model (in vivo, in vitro, human) | Type of cell line | Reference |
|---|---|---|---|---|---|---|
| miR-632 | up | TFF1 | induce | in vitro | BGC823, MGC803, EAhy926, MKN45 | Shi et al.179 |
| miR-612 | down | FOXM1 | inhibit | in vitro, in vivo | MKN-45, MKN-28, AGS, SGC-7901 | Wang et al.182 |
| miR-616-3p | up | PTEN/AKT/mTOR pathway | induce | in vitro | KN-28, MGC-80, GES-1, HEK293 T, AGS, SGC-7901 | Wu et al.176 |
| miR-532-5p | down | LINC01410 | inhibit | in vitro, in vivo | MNK-45, SGC-7901, AGS, HGC-27, BGC-23, GES-1 | Zhang et al.183 |
| miR-26a/b | down | HGF VEGF | inhibit | in vitro, in vivo | MKN-28, GES-1, AGS, HEK293 T, SGC-7901, MGC-80 | Si et al.184 |
| miR-1 | down | EDN1 VEGF-A | inhibit | in vitro, in vivo | SGC7901, MKN28, NCI-N87, BGC823, AGS, HGC27 | Xie et al.185 |
| miR-1228 | down | CK2A2 | inhibit | in vitro, in vivo | AGS, SGC-7901, HEK293T | Jia et al.186 |
| miR-218 | down | ROBO1 | inhibit | in vitro, in vivo | BGC-823, HUVEC-2C, HMVEC | Zhang et al.187 |
| miR-520b/e | down | EGFR | inhibit | in vitro | SGC-7901, MGC-803 | Li et al.188 |
| miR-101, miR-27b, miR-128 | down | VEGF-C | inhibit | in vitro, in vivo | MKN-45, SGC-7901, BGC-823 | Liu et al.189 |
| miR-125a | down | VEGF-A | inhibit | in vitro, human | GES-1, AGS, SGC7901, BCG-823, HUVEC | Dai et al.171 |
| miR-130a, miR-495 | up | RUNX3 | induce | in vitro | SNU5, SNU16, SNU484, MKN45, MKN1 | Lee et al.181 |
| miR-506 | down | ETS1 | inhibit | in vitro, human | AGS, SGC-7901, Kato-III, MKN45, BGC-823, HGC-27, MGC-803 | Li et al.190 |
| miR-874 | down | 3′ UTR of STAT3 | inhibit | in vitro, human | AGS, BGC823, MKN28, SGC-7901, GES-1 | Zhang et al.191 |
| miR-126 | down | VEGF-A | inhibit | in vitro, in vivo, human | SGC-7901, MKN-28, MKN-45 | Chen et al.192 |
| miR-29a/c | down | VEGF | inhibit | in vitro, human | HUVE, SGC790, HEK293T | Zhang et al.193 |
| miR-135a | down | focal adhesion kinase (FAK) | inhibit | in vitro, in vivo, human | MGC-803, MKN45, SGC-7901, BGC-823, MKN1, GES-1 | Cheng et al.194 |
| miRNA-145 | down | 3′ UTR of Ets1 | inhibit | in vitro, in vivo, human | SGC-7901, GES-1, MKN-45, HUVEC, AGS | Zheng et al.195 |
| miR-616-3p | up | PTEN | induce | in vitro, human | MGC-803, MKN-28, AGS, SGC-7901 | Wu et al.176 |
| miR-506 | up | ETS1 | inhibit | in vitro, human | Kato-III, SGC-7901, BGC-823, HGC-27, MKN45, MGC-803, AGS | Li et al.190 |