Table 7.
Angiogenesis-related circRNAs in GI cancers
| Cancer | CircRNA | Expression in gastric cancer | Target | Effect on angiogenesis (inhibit/induce) | Model (in vivo, in vitro, human) | Type of cell line | Reference |
|---|---|---|---|---|---|---|---|
| Pancreatic ductal adenocarcinoma | hsa_circ_001653 | up | HOXC6 | inhibit | in vitro, in vivo, human | Capan-2 (ZY-H431), SW1990(ZY-H338), PANC1 (ZY-H147), BxPC3 (ZY-H145) | Shi et al.287 |
| Hepatocellular carcinoma | hsa_circ_0000092 | up | HN1 | induce | in vitro, in vivo, human | Hep3B, LM3, MHCC97L, SK-hep1, HepG2 | Pu et al.291 |
| ircRNA-100338 | up | MMP2, MMP9 | induce | in vitro, in vivo, human | Hep3B, MHCC97L, MHCC97H, HLE, Huh7, BEL7402, SMCC7721 HCCLM3 and HCCLM6 | Huang et al.292 | |
| CircGFRA1 | up | miR-149 | induce | in vitro, human | SK-HEP-1, Huh6, Huh7, HCCLM3 | Yu et al.293 |