Table 2.
Glass Transition Temperature (Tg) and Moisture Content of Lumefantrine Dispersions with Tg Values of Pure Polymer and Drug (n = 3).
| Samples | Tg (°C) | 2:8 Lum:Polymer |
3:7 Lum:Polymer |
4:6 Lum:Polymer |
|||
|---|---|---|---|---|---|---|---|
| Tg (°C) | % Moisture Content | Tg (°C) | % Moisture Content | Tg (°C) | % Moisture Content | ||
| Lum | 18 | – | – | – | – | – | – |
| HPMCP | 150 | 88 ± 2 | 5 ± 0 | 112 ± 19 | 5 ± 0 | 110 ± 5 | 4 ± 1 |
| HPMCAS | 117 | 45 ± 2 | 5 ± 0 | 101 ± 22 | 6 ± 0 | 87 ± 1 | 5 ± 0 |
| CAP | 133 | Not performed | 82 ± 4 | 9 ± 0 | |||
The EL100 based ASDs and lower drug loadings of CAP-based ASDs were not tested due to the poor stability profile exhibited in the earlier studies.