Table 3.
Particle Sizes and Span of ASDs Before and After Vacuum Drying (n = 3).
| Polymer | Drug % | d10 (μm) | d50 (μm) | d90 (μm) | Span |
|---|---|---|---|---|---|
| HPMCP | 20% | 36.8 ± 1.6 | 139.0 ± 9.9 | 335.0 ± 33.5 | 2.15 ± 0.1 |
| 30% | 29.5 ± 0.3 | 99.2 ± 1.4 | 268.0 ± 5.7 | 2.40 ± 0.0 | |
| 40% | 31.9 ± 0.6 | 116.0 ± 3.6 | 378 ± 29.5 | 2.98 ± 0.2 | |
| HPMCP Dried | 20% | 60.8 ± 0.4 | 160 ± 1.4 | 367 ± 11.8 | 1.91 ± 0.1 |
| 30% | 19.8 ± 0.3 | 71.5 ± 0.8 | 213 ± 11.0 | 2.7 ± 0.1 | |
| 40% | 43.9 ± 2.2 | 147 ± 8.6 | 563 ± 161.3 | 3.53 ± 0.8 | |
| HPMCAS | 20% | 19.5 ± 0.2 | 62 ± 2.1 | 197.0 ± 24.1 | 2.86 ± 0.3 |
| 30% | 19.3 ± 0.7 | 56.2 ± 4.9 | 156.0 ± 22.8 | 2.43 ± 0.2 | |
| 40% | 18.9 ± 0.1 | 65.0 ± 2.2 | 171.0 ± 7.0 | 2.34 ± 0.0 | |
| HPMCAS Dried | 20% | 68.7 ± 8.7 | 1180 ± 90.0 | 2505 ± 15.0 | 2.06 ± 0.2 |
| 30% | 172 ± 4.9 | 444 ± 37.7 | 1870 ± 335.1 | 3.82 ± 0.5 | |
| 40% | 75.6 ± 1.7 | 366 ± 16.9 | 1130 ± 131.0 | 2.88 ± 0.4 | |
| CAP | 40% | 24 ± 1.1 | 76.7 ± 5.9 | 183 ± 20.2 | 2.07 ± 0.1 |
| CAP Dried | 40% | 28.1 ± 0.3 | 141 ± 6.8 | 575 ± 40.4 | 3.88 ± 0.1 |