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. 2021 May 10;12:659444. doi: 10.3389/fimmu.2021.659444

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Copyright © 2021 Yuan, Zhu, Lan, Duan, Zhu, Zhang, Li, Qu, Feng, Cai and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stratificaton of melanoma patients via the expression of 184 TIRGs. (A) 448 melanoma patients from TCGA dataset are classified into three clusters based on the selected TIRGs by optima selection of unsupervised clustering. (B) Principle component analysis on the expression level of 184 TIRGs. (C) Clinical characteristics and RNA expression level of 184 TIRGs of melanoma patients from cluster 1, 2 and 3. (D, E) ESTIMATE analysis of immune score (D) and stromal score (E) shows a significant difference among three clusters in melanoma patients. (F, G) Melanoma patients in cluster 2 and 3 have significantly longer overall survival (F) and longer disease-specific survival (G) than those in cluster 1.