Figure 3.

Construction of a risk score based on six signature genes. (A, B) The LASSO Cox regression model was constructed from 184 signature genes, and the tuning parameter (λ) was calculated based on the partial likelihood deviance with ten-fold cross validation. The six signature genes were identified according to the best fit profile. (C) Melanoma patients in the TCGA training set were divided into two populations according to the median value of the risk scores. (D–F) Melanoma patients with lower risk score have significantly longer survival in the TCGA whole set (D), GSE65094 data sets (E) and GSE22153 data sets (F).