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. 2021 May 10;12:659444. doi: 10.3389/fimmu.2021.659444

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Copyright © 2021 Yuan, Zhu, Lan, Duan, Zhu, Zhang, Li, Qu, Feng, Cai and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of risk score with immune activity. (A, B) Correlation between risk score and the infiltrating number of CD8 T cells in melanoma patients by analysis with TIMER (A) and CIBERSORT (B). (C) Comparison of seven T cell marker expression level between melanoma patients with high and low risk scores in the TCGA cohort. (D) Relationship between risk score and CD8+ T cell activation related genes. Adjusted P values were showed as: *P < 0.05; **P < 0.01; ***P < 0.001, ****P < 0.0001. (E) GSEA of gene expression from data sets TCGA_SKCM shows genes involving in CD8+ T cell infiltration signaling pathway mostly enriched in melanoma patients with low risk scores.