Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 10;11:595285. doi: 10.3389/fonc.2021.595285

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Hu, Cheng, Wang, Chen, Tu, Niu, Xing, Wang and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The combination of drugs significantly reduced the expression of AR and related genes. (A) Quantitative gene expression of SCAP, HMGCR, and CYP17A1. SK-N-BE (2) cells treated with Flu or/and AA for 24 h (the concentrations of drugs were as the same as that in Figure 4 ) to detect the expression of genes. GraphPad two-way analysis of variance (ANOVA) was used to analyze the expression differences of related genes. (B, C) Western blot assay (30 μg total protein per lane) was used to detect the expression of related proteins. (B) Simvastatin had significant effects on N2a and SH-SY5Y at 48 h, and SK-N-BE (2) had significant changes at 24 h. (C) Fluvastatin significantly reduced relative protein expression at 48 h. The data are reported as mean ± SD. * p < 0.05, ** p< 0.01.