Table 1.
Clinical parameters of PCOS participants classified by enterotypes.
| Control | PCOS | |||
|---|---|---|---|---|
| Bacteroides enterotype | Prevotella enterotype | Bacteroides enterotype | Prevotella enterotype | |
| Age(year) | 31(28-35) | 31(28-32) | 30(27-33) | 28.5(25.75-35.25) |
| Height(m) | 161(159-165) | 163(160-172) | 163(160-165) | 163(158-167.5) |
| Weight(m) | 57.75(53.25-65.3) | 60(57-75) | 75(62.5-83)* | 68.75(56.5-80.625) |
| BMI(kg/m2) | 22.19(19.90-25.01) | 22.83(22.03-25.35) | 26.95 (23.43-31.43)* | 25.69 (22.33-30.30) |
| Waistline(cm) | 75.5(72.75-82) | 83(76-90) | 88(79.5-101.25)* | 90.5(77.5-97.5) |
| Hipline(cm) | 94.5(90.75-100) | 98(93-101) | 100(93.75-107.75)* | 97.5(93-110) |
| WHR | 0.81(0.78-0.86) | 0.84(0.81-0.90) | 0.87 (0.83-0.92)* | 0.86 (0.83-0.94) |
| TP(g/L) | 74.5(71.6-76.8) | 73.05(69.95-75.95) | 77.9(74.9-80.85)* | 76.2(72.55-78.225) |
| ALB(g/L) | 46.3(44.2-48.2) | 44.4(41-48.525) | 47.5(44.7-50.1) | 46.6(45.3-50.375) |
| A/G | 1.66(1.54-1.81) | 1.58(1.39-1.71) | 1.57(1.43-1.72) | 1.625(1.555-1.88) |
| AST(U/L) | 14.2(11-17) | 17(16-20) | 19.5(16.25-24.5)* | 18.8(15.75-23.75) |
| ALT(U/L) | 12(8.5-14.5) | 14(12.25-16.5) | 21.5(14.5-37)* | 17.65(11.5-40.5) |
| GGT(U/L) | 12(10.5-17.1) | 13(10.5-20.25) | 24.5(16-37.5)* | 21.5(17.5-35.5) |
| ALP(U/L) | 64.6(57.85-71.3) | 66.7(56.87-82.52) | 82.4(64.65-98.32)* | 74.8(66.72-82.87) |
| PALB(g/L) | 0.253(0.24-0.2775) | 0.26(0.17-0.29) | 0.28(0.25-0.31) | 0.265(0.23-0.3) |
| CHE(U/L) | 7521(6539.5-9058.5) | 7849(6683.25-8602.25) | 9476(7853-10537)* | 8738.5(8268-9454.25) |
| TBIL(umol/L) | 10.8(9.45-14.85) | 13.6(10.45-18.23) | 9.9(8.4-12.375) | 10.2(9.675-16.175) |
| DBIL(umol/L) | 3.3(2.5-3.975) | 3.75(2.43-4.58) | 2.7(1.95-3.3) | 2.6(2.05-3.425) |
| IDBIL(umol/L) | 8.25(6.75-10.6) | 8.85(7.73-14.08) | 7.85(6-9.5) | 8.15(6.8-12.55) |
| TBA(umol/L) | 1.98(1.38-3.07) | 2.69(0.96-3.98) | 2.43(1.35-3.73) | 1.94(1.44-5.22) |
| MAO(U/L) | 5.3(4.5-6.81) | 5.58(4.33-7.03) | 6.69(5.92-7.70) | 5.75(4.17-9.06) |
| CHOL(mmol/L) | 4.34(4.19-4.65) | 5(3.99-5.46) | 4.77(4.4-5.8) | 4.65(4.28-5.13) |
| TG(mmol/L) | 0.72(0.56-1.21) | 0.84(0.58-1.17) | 1.29(0.98-2.16)* | 1.285(0.685-2.42) |
| HDL-C(mmol/L) | 1.58(1.145-1.87) | 1.3(1.17-1.5) | 1.2(1.02-1.4) | 1.105(0.85-1.7825) |
| LDL-C(mmol/L) | 2.56(2.28-3.14) | 3.27(2.44-3.45) | 2.97(2.36-4) | 2.73(2.41-3.4675) |
| apoA1(g/L) | 1.52(1.33-1.68) | 1.55(1.39-1.71) | 1.40(1.28-1.56) | 1.35 (1.14-1.56) |
| apoB(g/L) | 0.68(0.61-0.86) | 0.83(0.66-0.96) | 0.91(0.79-1.11)* | 1.01(0.80-1.18) |
| sd-LDL(mmol/L) | 0.58(0.51-1.08) | 0.77(0.67-1.13) | 0.97 (0.85-1.44)* | 1.02 (0.55-1.47) |
| FPG(mmol/L) | 5.24(4.82-5.51) | 5.22(4.89-5.43) | 5.16(4.95-5.52) | 5.3(4.77-5.88) |
| 25(OH)-VitD(ng/mL) | 13.58(10.48-18.51) | 13.12(12.06-16.97) | 12.97(10.03-16.49) | 13.04(10.09-16.84) |
| Prog(ng/mL) | 0.63(0.27-0.76) | 0.58(0.26-0.69) | 0.47(0.24-0.70) | 0.44(0.20-0.50) |
| PRL(ng/mL) | 11.83(9.42-15.36) | 12.55(8.82-16.31) | 7.85(6.02-13.05) | 10.06(7.17-13.29) |
| SHBG(nmol/L) | 44.9(33.8-87.4) | 50.3(36.65-88.2) | 17.4(12.15-35.5)* | 19.15(13.5-38.55) |
| FAI(%) | 3.4(1.83-4.67) | 2.92(2.29-6.57) | 13.39(6.93-22.69)* | 12.67(4.06-18.65) |
| TT(ng/mL) | 0.43(0.35-0.55) | 0.44(0.37-0.69) | 0.68(0.51-0.78)* | 0.69(0.445-0.9) |
| LH(mIU/mL) | 3.82(2.97-5.02) | 3.42(2.66-4.74) | 8.36(4.78-10.25)* | 8.89(5.41-12.187)# |
| FSH(mIU/mL) | 7.31(6.49-8.94) | 7.07(6.34-8.4) | 6.28(5.40-7.32) | 6.52(5.5475-7.42) |
| E2(pg/mL) | 50(37-69.5) | 61(43-84) | 51(34.75-72.75) | 49(36-74.5) |
| FT3(pmol/L) | 4.57(4.19-4.745) | 4.61(4.095-5.2) | 4.9(4.54-5.07) | 4.89(4.57-5.30) |
| FT4(pmol/L) | 12.65(11.945-13.82) | 13.51(12.82-14.66) | 12.80(11.77-13.44) | 12.92(10.97-14.24) |
| TSH(uIU/mL) | 2.01(1.39-2.29) | 1.81(1.02-2.89) | 1.71 (1.04-2.42) | 1.29(1.08-3.22) |
| FINS(mU/L) | 8.9(7.15-11.45) | 7.45(6.02-9.17) | 18.2(9.68-23)* | 11.2(8.55-23.62) |
| AMH(ng/mL); | 3.29(1.81-5.45) | 2.57(2.19-3.23) | 6.78(4.52-12.86)* | 9(6.07-11.61)# |
| HOMA-IR | 2.02(1.61-2.59) | 1.65(1.37-2.22) | 4.02 (2.13-5.66)* | 2.55 (1.90-6.23) |
PCOS, polycystic ovary syndrome.
Data are presented as Median (IQR).
WHR, waist-to-hip ratio; TP, total protein; ALB, albumin; A/G, albumin/globulin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyltransferase; ALP, alkaline phosphatase; PALB, prealbumin; CHE, cholinesterase; TBIL, total bilirubin; DBIL, direct bilirubin; IDBIL, indirect bilirubin; TBA, total bile acid; MAO, monoamine oxidase; CHOL, total cholesterol; TG, triglycerides; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; apoA1, apolipoprotein A1; apoB, apolipoprotein B; sd-LDL, small dense low-density lipoprotein–cholesterol; FPG, fasting plasma glucose; 25-(OH)VitD, 25-hydroxy vitamin D determination; Prog, progesterone; PRL, prolactin; SHBG, sex hormone–binding globulin; FAI, free androgen index; TT, total testosterone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; E2, estradiol; FT3, free triiodothyronine 3; FT4, free triiodothyronine 4; TSH, thyroid stimulating hormone; FINS, fasting plasma insulin; AMH, anti-Müllerian hormone; HOMA-IR, homeostasis model assessment.
*PCOS with Bacteroides enterotype vs. control with Bacteroides enterotype. #PCOS with Prevotella enterotype vs. control with Prevotella enterotype.