Figure 1.
Possible miRNA-to-mRNA expression relationships in Alzheimer’s disease (AD) and cancer
(A) Heatmap of differentially expressed miRNAs in prefrontal cortex of AD patients. The significance threshold for selection of differentially expressed miRNAs was considered as fold change of ±1.25 and a p value of ≤0.05. (B) Graphs showing expression levels of miR-146a targets in the prefrontal cortex of Alzheimer’s disease patients. The y axis represents fold change of individual mRNAs, and the x axis represents the –log10 p value. The table represents the number of miR-146a targets having at least 1.5-fold changes. (C) The probable relationship between differentially expressed miRNAs and mRNAs in AD considering the possible fraction of upregulated target mRNAs of each of the miRNAs as studied in different cortical regions (frontal cortex, superior frontal gyrus, and dorsolateral prefrontal cortex) is depicted here. (D) Percentages of upregulated or downregulated miRNAs that possibly have a fraction of their target genes as upregulated within the frontal cortex, superior frontal gyrus, and dorsolateral prefrontal cortex are shown here. (E) Comparison among the percentages of differentially expressed miRNAs that have different subsets or fractions of their target mRNAs as upregulated in degenerative tissues (AD) as opposed to highly proliferative tissues (cancer) was performed.