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Proposed Mechanistic Effects of Fat-Derived C16:0-Ceramide
Dysfunctional thoracic adipose tissue in obese cardiac patients secretes higher levels of C16:0-ceramide (Cer16:0), increasing its circulating levels. Acting via endothelial nitric oxide synthase signaling, circulating Cer16:0 enhances systemic inflammation, amplifies oxidative stress, and reduces endothelium-dependent vasorelaxation, eventually leading to adverse cardiac outcomes including death.
