TABLE 3.
Common POI-related genes in humans and mice.
| Genes | Full name | Function | References |
| ATM | Ataxia telangiectasia mutated | A member of the phosphatidylinositol-3 kinase-like protein kinase (PIKK) family | Liu H. et al., 2020 |
| BMP15 | Bone morphogenetic protein 15 | Growth factor beta | di Pasquale et al., 2004 |
| BMPR1A/1B | Bone morphogenetic protein receptor, type IB | Growth factor beta | Renault et al., 2020 |
| CLPP | ClPP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (Escherichia coli) | Cytochrome P450 family 19 subfamily A member 1 | Jenkinson et al., 2013 |
| CSB-PGBD3* | CSB-PGBD3 fusion protein | DNA damage repair | Qin et al., 2015a |
| CYP19A1 | Cytochrome P450, family 19, subfamily A, polypeptide 1 | Cytochrome P450 family 19 subfamily A member | Kim et al., 2011 |
| eIF4ENIF1* | Eukaryotic translation initiation factor 4E nuclear import factor 1 | Regulates translation and stability of mRNAs in processing bodies | Zhao et al., 2019 |
| ERCC6 | DNA excision repair protein ERCC-6 | Essential factor involved in transcription-coupled nucleotide excision repair | Qin et al., 2015b |
| FANCA | Fanconi anemia, complementation group A | DNA repair protein | Pyun et al., 2014 |
| FOXL2 | Forkhead box L2 | Transcription factor | Park et al., 2014 |
| FSHR | Follicle stimulating hormone receptor | Receptor | Aittomäki et al., 1995; Huang et al., 2019 |
| HFM1* | HFM1, ATP-dependent DNA helicase homolog (Saccharomyces cerevisiae) | Receptor | Zhe et al., 2019 |
| MCM8/9* | Minichromosome maintenance component 8 | DNA-repair gene | Wood-Trageser et al., 2014; AlAsiri et al., 2015; Desai et al., 2017 |
| MSH4/5* | MutS protein homolog 4/5 | Homologous recombination (HR) repair for DNA double strand breaks | Carlosama et al., 2017; Guo et al., 2017; Wang et al., 2020 |
| NANOS3 | Nanos homolog 3 (Drosophila) | Signaling molecule | Wu et al., 2013 |
| NBN | Nibrin | DAN-repair gene | Chrzanowska et al., 2010; Tucker et al., 2018 |
| NR5A1 | Nuclear receptor subfamily 5, group A, member 1 | Receptor | Lourenço et al., 2009 |
| NUP107* | Nucleoporin 107 kDa | Receptor | Weinberg-Shukron et al., 2015 |
| PGRMC1 | Progesterone receptor membrane component 1 | Cell cycle gene meiotic recombination | Peluso, 2013 |
| PRIM1 | DNA primase small subunit | DNA replication | Stolk et al., 2012 |
| PSMC3IP* | PSMC3 interacting protein | Cell cycle genes | Zangen et al., 2011 |
| SALL4 | Spalt-like transcription factor 4 | Oogenesis | Wang et al., 2019 |
| SGO2 | Shugoshin 2 | Transcription factors | Faridi et al., 2017 |
| SOHLH1 | Spermatogenesis and oogenesis specific basic helix-loop-helix 1 | Cell cycle genes | Zhao et al., 2015 |
| SPIDR* | Scaffolding protein involved in DNA repair | Homologous recombination repair during meiosis | Smirin-Yosef et al., 2017 |
| STAG3* | Stromal antigen 3 | DNA-damage | Heddar et al., 2019 |
| StAR | Steroidogenic acute regulatory protein | Acute regulation of steroid hormone synthesis | Jehaimi et al., 2010 |
| SYCE1* | Synaptonemal complex central element protein 1 | Growth factor beta | de Vries et al., 2014 |
| WRN | Werner syndrome protein; Werner syndrome, RecQ helicase-like | Caseinolytic mitochondrial matrix peptidase | Du et al., 2004 |
*Identified from GWAS.